Clinical Trials

Chordoma

NCT04087902 2026-05-20

Long-Term Longitudinal QoL in Patients Undergoing EEA

Active not recruiting

400 enrolled

Chondrosarcoma, Chordoma, Craniopharyngioma, Encephalocele, Meningioma, Pituitary Neoplasms, Esthesioneuroblastoma, Olfactory, Central Nervous System Cysts

NCT02834013 2026-05-13

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

CNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckSarcoma

818 enrolled

Nasopharyngeal Carcinoma, Bile Duct Neoplasms, Carcinoma, Basal Cell, Adenocarcinoma, Bronchiolo-Alveolar, Adenocarcinoma, Mucinous, Carcinoma, Transitional Cell, Carcinosarcoma, Chordoma, Carcinoma, Adenoid Cystic, Fibroma, Gallbladder Neoplasms, Hemangiosarcoma, Mouth Neoplasms, Paget Disease, Extramammary, Paraganglioma, Paranasal Sinus Neoplasms, Parathyroid Neoplasms, Pheochromocytoma, Pseudomyxoma Peritonei, Somatostatinoma, Thyroid Neoplasms, Vulvar Neoplasms, Desmoid Tumors, Seminoma, Carcinoma, Acinar Cell, Adrenocortical Carcinoma, Carcinoma, Endometrioid, Cholangiocarcinoma, Cystadenocarcinoma, Mucinous, Cystadenocarcinoma, Serous, Carcinoma, Giant Cell, Neurofibrosarcoma, Gestational Trophoblastic Disease, Rare Diseases, Gastrointestinal Stromal Tumors, Perivascular Epithelioid Cell Neoplasms

NCT05286801 2026-05-13

Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

Phase 1/2 Active not recruiting

86 enrolled

Phase 1/2 Active not recruiting

Chordoma, Sarcoma, Rhabdoid Tumor

NCT06957327 2026-04-28

A Study of ERAS-601 in People With Chordoma

12 enrolled

Phase 1/2 Active not recruiting

Chordoma

NCT05407441 2026-04-13

Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors

49 enrolled

Chordoma, Sarcoma, Rhabdoid Tumor

NCT06787664 2026-04-13

A Study of BL-B01D1 in Patients With Locally Advanced or Metastatic Chordoma

27 enrolled

Phase 1 Active not recruiting

Chordoma

NCT04670679 2026-03-25

FLAGSHP-1

90 enrolled

GastrointestinalHead & NeckSarcoma

Squamous Cell Carcinoma of Head and Neck, Chordoma, Neoplasm Metastasis, Neoplasms, Noonan Syndrome, Colorectal Neoplasms

NCT01046487 2026-03-13

PALANGI3

DermatologicGastrointestinalSarcoma

26 enrolled

Uveal Melanoma, Chordoma, Carcinoma, Adenoid Cystic, Neoplasms, Desmoid Tumors, Dermatofibrosarcoma, Gastrointestinal Stromal Tumors

NCT05033288 2026-03-13

Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone

Recruiting

72 enrolled

BreastGastrointestinalGenitourinaryGynecologicSarcomaThoracic

Bone Neoplasms, Chondrosarcoma, Chordoma

NCT06625190 2026-03-11

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

Phase 1/2 Recruiting

27 enrolled

CNSSarcoma

Chordoma, Myoepithelioma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Sarcoma, Clear Cell, Sarcoma, Alveolar Soft Part, Nerve Sheath Neoplasms, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT04091295 2026-03-04

BLESSED: Expanded Access for DNG64-CAR-V for Advanced Pancreatic Cancer, Sarcoma and Carcinoma of Breast

Available

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Chondrosarcoma, Chordoma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Osteosarcoma, Neurofibrosarcoma

NCT05041127 2026-02-19

Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma

29 enrolled

Chordoma

NCT05861245 2026-01-23

Hypofractionated Protontherapy in Chordomas and Chondrosarcomas of the Skull Base

Phase NA Recruiting

20 enrolled

Phase 1 Active not recruiting

Chondrosarcoma, Chordoma

NCT02989636 2026-01-06

Nivolumab With or Without Stereotactic Radiosurgery in Treating Patients With Recurrent, Advanced, or Metastatic Chordoma

21 enrolled

Chordoma

NCT02986516 2026-01-02

SACRO

Phase NA Recruiting

100 enrolled

Chordoma

NCT01407198 2025-12-19

Nilotinib With Radiation for High Risk Chordoma

23 enrolled

Chordoma

NCT04416568 2025-12-17

Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

45 enrolled

Chordoma, Sarcoma, Rhabdoid Tumor

NCT00496119 2025-12-16

Proton Beam Therapy for Chordoma Patients

19 enrolled

Chordoma

NCT01449149 2025-12-05

Proton Radiation for Chordomas and Chondrosarcomas

Phase NA Completed

54 enrolled 11 charts

Chondrosarcoma, Chordoma

NCT02936102 2025-11-14

A Study of FAZ053 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies.

Phase 1 Terminated

154 enrolled

BreastSarcoma

Chordoma, Sarcoma, Alveolar Soft Part, Triple Negative Breast Neoplasms

NCT06535997 2025-08-06

PRIMHADRON

62 enrolled

LymphoidSarcoma

Chondrosarcoma, Chordoma, Carcinoma, Adenoid Cystic, Hemangiosarcoma, Lymphoma, Follicular, Neoplasms, Sarcoma, Osteosarcoma

NCT04246671 2025-03-03

TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer

37 enrolled

Chordoma

NCT03647423 2025-02-21

QUILT-3.091 NANT Chordoma Vaccine vs Radiation in Subjects With Unresectable Chordoma.

Phase 1/2 Withdrawn

DermatologicGastrointestinalGenitourinarySarcomaThoracic

Chordoma

NCT03190174 2025-02-17

Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers

Phase 1/2 Completed

34 enrolled 14 charts

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Chordoma, Carcinoma, Hepatocellular, Melanoma, Sarcoma, Sarcoma, Ewing, Colorectal Neoplasms, Desmoid Tumors, Perivascular Epithelioid Cell Neoplasms

NCT03083678 2025-02-13

Afatinib in Locally Advanced and Metastatic Chordoma

43 enrolled

Chordoma

NCT06794645 2025-01-27

Pembrolizumab and Pemetrexed for Progressive Chordoma

Phase 2 Recruiting

21 enrolled

Chordoma

NCT05355753 2024-12-17

A Study to Assess the Safety and Tolerability of CFT8634 in Locally Advanced or Metastatic SMARCB1-Perturbed Cancers, Including Synovial Sarcoma and SMARCB1-Null Tumors

Phase 1 Terminated

49 enrolled

Chondrosarcoma, Extraskeletal Myxoid, Chordoma, Sarcoma, Sarcoma, Synovial

NCT06029218 2024-09-25

P1V2

Phase NA Recruiting

106 enrolled

Chondrosarcoma, Chordoma, Sarcoma, Ewing, Osteosarcoma

NCT02383498 2024-05-20

QUILT-3.011 Phase 2 Yeast-Brachyury Vaccine Chordoma

24 enrolled 8 charts

Chordoma

NCT03623854 2024-04-16

Nivolumab and Relatlimab in Treating Participants With Advanced Chordoma

10 enrolled

Chordoma

NCT03242382 2024-01-23

PalboSarc

40 enrolled

Chordoma, Sarcoma, Osteosarcoma

NCT01811394 2023-12-06

ISAC

100 enrolled

Chordoma

NCT06140732 2023-11-20

Apatinib Combined With Camrelizumab in Treating Participants With Advanced Chordoma

30 enrolled

Chordoma

NCT04832620 2023-11-18

CHIPT

Recruiting

40 enrolled

Chondrosarcoma, Chordoma

NCT00919269 2023-10-03

Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma

150 enrolled

Chordoma, Rhabdomyosarcoma, Sarcoma, Desmoid Tumors, Desmoplastic Small Round Cell Tumor

NCT05707767 2023-07-19

A Prospective Study of Surgical Treatment Strategies for Chordoma

Phase NA Unknown

100 enrolled

Chordoma

NCT03595228 2023-04-14

BN Brachyury and Radiation in Chordoma

29 enrolled 20 charts

Chordoma

NCT03110744 2023-03-27

NCT-PMO-1601

43 enrolled

Chordoma

NCT03955042 2023-03-07

Pemetrexed for the Treatment of Chordoma

15 enrolled

Chordoma

NCT02520128 2020-12-02

IMRiS

Phase NA Completed

191 enrolled

Bone Neoplasms, Chordoma, Sarcoma, Sarcoma, Ewing

NCT04486820 2020-07-27

CHORDOMES

40 enrolled

Chordoma

NCT00341627 2020-07-10

Genetic Aspects of Chordoma: A Collaboration With SEER Registries to Identify Chordoma Families

56 enrolled

Bone Neoplasms, Chordoma

NCT01347307 2020-06-18

Stereotactic Body Radiotherapy for Spine Tumors

Phase NA Completed

38 enrolled 11 charts

Arteriovenous Malformations, Chordoma, Meningioma, Neurilemmoma, Neurofibroma, Paraganglioma

NCT00410670 2019-12-17

Chordoma Family Study

55 enrolled

Chordoma

NCT01924689 2019-09-09

Safety Study of Intratumoral Injection of Clostridium Novyi-NT Spores to Treat Patients With Solid Tumors That Have Not Responded to Standard Therapies

24 enrolled 18 charts

Hypoxia, Chordoma, Necrosis, Neoplasm Metastasis, Neoplasms, Sarcoma

NCT01966809 2019-08-20

Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas

Phase 2 Terminated

1 enrolled 5 charts

Astrocytoma, Brain Neoplasms, Chordoma, Craniopharyngioma, Glioblastoma, Glioma, Meningioma, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Pituitary Neoplasms, Germinoma, Optic Nerve Glioma

NCT04042597 2019-08-05

CSSG-03

60 enrolled

Chordoma

NCT01682746 2019-02-25

Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors

5 enrolled