Clinical Trials

Adrenal Gland Neoplasms, Cushing Syndrome

NCT07412782 2026-02-17

REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD)

Phase NA Recruiting

100 enrolled

EndocrineOther

Bone Diseases, Metabolic, Cushing Syndrome, Dwarfism, Pituitary, Neoplasms, Obesity, Osteogenesis Imperfecta, Osteoporosis, Malnutrition, Overweight

NCT07104812 2026-02-11

Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)

Phase 2 Recruiting

15 enrolled

ACTH Syndrome, Ectopic, Adrenal Hyperplasia, Congenital, Cushing Syndrome

NCT06573723 2026-01-14

Institutional Registry of Rare Diseases

CNSDermatologicEndocrineMyeloidPlasma cell

380 enrolled

Immunoglobulin G4-Related Disease, Adrenal Hyperplasia, Congenital, Amyloidosis, Cardiomyopathy, Hypertrophic, Cushing Syndrome, Demyelinating Diseases, Gaucher Disease, Hepatolenticular Degeneration, von Hippel-Lindau Disease, Hirschsprung Disease, Hypertension, Pulmonary, Mastocytosis, Metabolism, Inborn Errors, Multiple Endocrine Neoplasia, Paraganglioma, Pheochromocytoma, Prader-Willi Syndrome, Sarcoidosis, Telangiectasia, Hereditary Hemorrhagic, Inflammatory Bowel Diseases, Neurocutaneous Syndromes, Rare Diseases, Vascular Malformations, Angioedemas, Hereditary, Eosinophilic Esophagitis

NCT07247162 2025-12-10

LINC CARE

Phase 4 Not yet recruiting

63 enrolled

ACTH Syndrome, Ectopic, Cushing Syndrome, Hypertension

NCT06246357 2025-12-09

Evaluating the Functional Status of the Adrenal Glands With [68Ga]Ga-PentixaFor in Hyperaldosteronism and Hypercortisolism

Phase 2 Recruiting

80 enrolled

Adenoma, Cushing Syndrome, Hyperaldosteronism

NCT03364803 2025-10-23

Collecting Information About Treatment Results for Patients With Cushing's Syndrome

300 enrolled

Cushing Syndrome, Pituitary ACTH Hypersecretion

NCT05307328 2025-10-08

RESCUE

Phase 2 Completed

26 enrolled

Phase 2 Active not recruiting

ACTH Syndrome, Ectopic, Cushing Syndrome, Pituitary ACTH Hypersecretion

NCT06106295 2025-09-22

Metyrapone for Mild Autonomous Cortisol Secretion (MACS)

30 enrolled

ACTH Syndrome, Ectopic, Adrenal Hyperplasia, Congenital, Cushing Syndrome

NCT04308590 2025-09-04

GRADIENT

Phase 2 Not yet recruiting

137 enrolled 25 charts

ACTH Syndrome, Ectopic, Cushing Syndrome, Diabetes Mellitus, Type 2, Hypertension

NCT07138274 2025-08-22

Metyrapone Study for Patients Diagnosed With Mild Autonomous Cortisol Secretion - MACS

90 enrolled

ACTH Syndrome, Ectopic, Adrenal Hyperplasia, Congenital, Cushing Syndrome

NCT03697109 2025-07-16

GRACE

152 enrolled 28 charts

ACTH Syndrome, Ectopic, Cushing Syndrome, Diabetes Mellitus, Type 2, Hypertension, Pituitary ACTH Hypersecretion

NCT05804669 2025-04-10

A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome

Phase 1/2 Recruiting

18 enrolled

ACTH Syndrome, Ectopic, Cushing Syndrome, Pituitary ACTH Hypersecretion

NCT04127552 2025-03-28

ITACA

68 enrolled

Adrenal incidentaloma, Adrenal Gland Neoplasms, Cushing Syndrome

NCT06701838 2024-12-03

OPTIMAL

Not yet recruiting

15 enrolled

Cushing Syndrome, Pituitary Neoplasms, Pituitary ACTH Hypersecretion, ACTH-Secreting Pituitary Adenoma

NCT06326853 2024-06-11

Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models

Not yet recruiting

200 enrolled

EndocrineOther

Acromegaly, Cushing Syndrome, Endocrine System Diseases, Hypopituitarism, Obesity, Pituitary Neoplasms

NCT06229405 2024-03-04

Development of Clinical Evidence for Optimal Management of Adrenal Diseases Based on Real-World Data

Unknown

8,200 enrolled

Adrenal Gland Neoplasms, Cushing Syndrome, Hyperaldosteronism, Pheochromocytoma, Adrenocortical Carcinoma

NCT04373265 2024-02-23

Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)

Phase 1 Completed

15 enrolled

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Adrenal Gland Diseases, Adrenocortical Hyperfunction, Cushing Syndrome, Diabetes Mellitus, Type 2, Endocrine System Diseases, Hyperglycemia, Hypertension, Pathologic Processes, Glucose Intolerance, Adrenocortical Carcinoma

NCT05456997 2023-10-16

LYDIA

Terminated

1 enrolled

Cushing Syndrome, Hyperaldosteronism, Pheochromocytoma

NCT06050057 2023-09-22

Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted Adrenalectomy

100 enrolled

Adrenal Cortex Diseases, Adrenal Cortex Neoplasms, Adrenal Gland Diseases, Adrenal Gland Neoplasms, Adrenal Hyperplasia, Congenital, Cushing Syndrome, Pheochromocytoma, Adrenocortical Adenoma, Adrenocortical Carcinoma

NCT05347979 2023-02-09

Effect of Relacorilant on the Pharmacokinetics of the Sensitive P-glycoprotein Substrate Dabigatran Etexilate in Healthy Participants

Phase 1 Completed

30 enrolled

Cushing Syndrome, Neoplasms

NCT04890444 2022-02-14

CASE

Unknown

2,000 enrolled

Adrenal incidentaloma, ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Adrenal Insufficiency, Adrenal Hyperplasia, Congenital, Cushing Syndrome, Hyperaldosteronism, Pheochromocytoma

NCT04433819 2020-06-16

Nailfold Capillaroscopy Evaluation in Cushing Syndrome Patients

Unknown

200 enrolled

ACTH Syndrome, Ectopic, Cushing Syndrome, Pituitary ACTH Hypersecretion

NCT02468193 2020-05-06

Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome

Phase 2 Completed

9 enrolled 22 charts

Acth-Independent Macronodular Adrenal Hyperplasia, ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Cushing Syndrome

NCT03474237 2020-03-18

A Prospective Cohort Study for Patients With Adrenal Diseases

Enrolling by invitation

1,500 enrolled

Adrenal incidentaloma, ACTH Syndrome, Ectopic, Cushing Syndrome, Hyperaldosteronism, Pheochromocytoma, Adrenocortical Carcinoma

NCT02804750 2019-10-15

Study to Evaluate CORT125134 in Participants With Cushing's Syndrome

Phase 2 Completed

35 enrolled 13 charts

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Cushing Syndrome, Diabetes Mellitus, Type 2, Hypertension, Adrenocortical Carcinoma, Pituitary ACTH Hypersecretion

NCT00422201 2019-10-11

Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion

Phase 2 Terminated

18 enrolled 9 charts

ACTH Syndrome, Ectopic, Cushing Syndrome

NCT02001051 2018-06-14

Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism

Phase 2 Terminated

4 enrolled 10 charts

EndocrineOther

Adrenal incidentaloma, Adrenal Gland Neoplasms, Cushing Syndrome, Diabetes Mellitus, Hypercholesterolemia, Hypertension, Obesity, Osteoporosis

NCT02574793 2018-01-23

Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects

Completed

60 enrolled

Cushing Syndrome, Pituitary Neoplasms

NCT01676025 2017-10-06

PRA

Phase NA Completed

83 enrolled

Adrenal incidentaloma, Adrenal Gland Diseases, Cushing Syndrome, Hyperaldosteronism, Pheochromocytoma

NCT03145285 2017-05-10

ABACUS

Phase 2 Unknown

10 enrolled

Cushing Syndrome, Adrenocortical Carcinoma

NCT02618694 2017-03-03

PostLapAdrnl

Phase NA Completed

13 enrolled

Adrenal Gland Diseases, Cushing Syndrome, Pheochromocytoma

NCT02543697 2016-09-08

AVS

Phase NA Unknown

30 enrolled

Cushing Syndrome

NCT00796783 2014-06-20

A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia

Terminated

2 enrolled

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Choristoma, Cushing Syndrome, Hirsutism, Pituitary Diseases, Pituitary ACTH Hypersecretion

NCT00936741 2014-04-02

An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome

30 enrolled 8 charts

ACTH Syndrome, Ectopic, Adrenal Cortex Neoplasms, Choristoma, Cushing Syndrome, Hirsutism, Pituitary Diseases, Pituitary ACTH Hypersecretion

NCT01371565 2014-03-18

Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome

4 enrolled 7 charts

ACTH Syndrome, Ectopic, Cushing Syndrome, Pituitary Diseases, Pituitary ACTH Hypersecretion

NCT01959711 2013-10-10

Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy

Phase 4 Completed

65 enrolled

Adrenal Gland Neoplasms, Cushing Syndrome, Hyperaldosteronism, Pheochromocytoma

NCT00569582 2013-08-22

SEISMIC

50 enrolled 8 charts