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Phase

Phase 2 1Phase 1/2 1Phase 1 1

Status

Completed 2Terminated 1

Sponsor Class

OTHER 2INDUSTRY 1

Study Type

Interventional 3

Sponsor

Cancer Type

CNS 3Thoracic 1Lymphoid 1Head & Neck 1Gynecologic 1Gastrointestinal 1Dermatologic 1

Conditions

Carcinoma, Non-Small-Cell Lung 10Parkinson Disease 4, Autosomal Dominant Lewy Body 9Squamous Cell Carcinoma of Head and Neck 8Ovarian Neoplasms 8Melanoma 8Head and Neck Neoplasms 8Lung Neoplasms 6Neoplasms 5Fallopian Tube Neoplasms 5Colorectal Neoplasms 4Carcinoma, Transitional Cell 4Stomach Neoplasms 3Neoplasm Metastasis 3Lymphoma 3Glioblastoma 3Endometrial Neoplasms 3Carcinoma, Renal Cell 3Triple Negative Breast Neoplasms 2Small Cell Lung Carcinoma 2Pancreatic Neoplasms 2Esophageal Neoplasms 2Carcinoma, Ovarian Epithelial 2Carcinoma, Hepatocellular 2Uveal Melanoma 1Uterine Cervical Neoplasms 1Urinary Bladder Neoplasms 1Unresectable or Metastatic Solid Tumors 1Thymus Neoplasms 1Thymoma 1Spinocerebellar Degenerations 1

Interventions

Temozolomide 405Radiotherapy 202Bevacizumab 157Radiation 80Magnetic Resonance Spectroscopy 77Lomustine 49Surgical Procedures, Operative 45Carmustine 41pembrolizumab 40Irinotecan 38Nivolumab 32Specimen Handling 28Carboplatin 27Radiosurgery 24Erlotinib Hydrochloride 24Drug Therapy 23Chemotherapy, Adjuvant 23Radiotherapy, Intensity-Modulated 22Cyclophosphamide 20Aminolevulinic Acid 20O(6)-benzylguanine 17sargramostim 16Radiotherapy, Conformal 15Blood Specimen Collection 15temsirolimus 14Granulocyte-Macrophage Colony-Stimulating Factor 14Everolimus 14Vorinostat 13Sorafenib 13Ipilimumab 13

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

3 trials
RecentStart dateEnrollment
Glioblastoma × epacadostat × Clear all
NCT03532295 2025-11-21

Retifanlimab and Epacadostat in Combination With Radiation and Bevacizumab in Patients With Recurrent Gliomas

Washington University School of Medicine

Phase 2 Completed
51 enrolled 16 charts
CNS

Glioblastoma, Glioma

NCT02327078 2025-08-14

A Study of the Safety, Tolerability, and Efficacy of Epacadostat Administered in Combination With Nivolumab in Select Advanced Cancers (ECHO-204)

Incyte Corporation

Phase 1/2 Completed
307 enrolled 27 charts
CNSDermatologicGastrointestinalGynecologicHead & NeckLymphoidThoracic

Glioblastoma, Head and Neck Neoplasms, Lung Neoplasms, Lymphoma, Melanoma, Ovarian Neoplasms, Colorectal Neoplasms

NCT03707457 2020-07-02

Biomarker-Driven Therapy Using Immune Activators With Nivolumab in Patients With First Recurrence of Glioblastoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Phase 1 Terminated
3 enrolled
CNS

Glioblastoma

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