Clinical Trials Browser

Phase 1 × Glioblastoma × Clear all

NCT03451799 2026-04-15

Ketogenic Diet in Combination With Standard-of-care Radiation and Temozolomide for Patients With Glioblastoma

Phase 1 Completed

Glioblastoma

NCT06641908 2026-04-15

Anti-GD2 ADC M3554 in Advanced Solid Tumors

Phase 1 Recruiting

Glioblastoma, Sarcoma

NCT00268385 2026-04-13

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

Phase 1 Active not recruiting

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02381886 2026-04-13

A Study of IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations

Phase 1 Active not recruiting

CNSGastrointestinalMyeloidOther hematologic neoplasm

Astrocytoma, Glioblastoma, Glioma, Leukemia, Myelodysplastic Syndromes, Oligodendroglioma, Leukemia, Myeloid, Acute, Cholangiocarcinoma

NCT03911388 2026-04-13

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Phase 1 Recruiting

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT05168423 2026-04-13

CART-EGFR-IL13Ra2 in EGFR Amplified Recurrent GBM

Phase 1 Active not recruiting

Glioblastoma

NCT06860594 2026-04-13

Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

Phase 1 Suspended

Astrocytoma, Glioblastoma, Lymphoma, Follicular

NCT07422363 2026-04-13

Testing the Combination of Anti-cancer Drugs Actimab-A and Cemiplimab (REGN2810) to Improve Outcomes for Patients With Recurrent Glioblastoma

Phase 1 Not yet recruiting

Glioblastoma, Gliosarcoma

NCT06344130 2026-04-09

Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Phase 1 Recruiting

Astrocytoma, Glioblastoma, Glioma

NCT07134842 2026-04-09

WinGlio-ipi

Phase 1 Recruiting

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT04978727 2026-04-06

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Phase 1 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Ependymoma, Glioblastoma, Medulloblastoma, Oligodendroglioma

NCT07497373 2026-04-03

JL15003

Phase 1 Completed

Glioblastoma

NCT05789394 2026-04-02

Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy

Phase 1 Recruiting

Astrocytoma, Glioblastoma

NCT06650605 2026-03-31

CITADEL-123

Phase 1 Completed

Glioblastoma

NCT04197934 2026-03-30

WSD0922-FU for the Treatment of Glioblastoma, Anaplastic Astrocytoma, or Non-small Cell Lung Cancer With Central Nervous System Metastases

Phase 1 Active not recruiting

Astrocytoma, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Lung Neoplasms

NCT06934889 2026-03-30

Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma

Phase 1 Recruiting

Glioblastoma, Gliosarcoma

NCT04019002 2026-03-27

Hyperpolarized Carbon-13 (13C) Pyruvate Imaging in Patients With Glioblastoma

Phase 1 Completed

Glioblastoma

NCT05139056 2026-03-27

Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas

Phase 1 Suspended

Glioblastoma

NCT05303467 2026-03-27

FRONTIER

Phase 1 Recruiting

Glioblastoma

NCT05283330 2026-03-20

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

Phase 1 Recruiting

BreastCNSGastrointestinalGenitourinaryGynecologicThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Colonic Neoplasms, Glioblastoma, Neoplasm Metastasis, Prostatic Neoplasms, Recurrence, Colorectal Neoplasms

NCT07464925 2026-03-20

A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

Phase 1 Not yet recruiting

Glioblastoma, Glioma

NCT04573140 2026-03-19

PNOC020

Phase 1 Active not recruiting

Brain Neoplasms, Glioblastoma, Glioma, Lymphoma, Follicular

NCT03478462 2026-03-18

CLOVER-2

Phase 1 Active not recruiting

CNSGenitourinaryLymphoidSarcoma

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioblastoma, Glioma, Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT04678648 2026-03-18

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

Phase 1 Recruiting

CNSGastrointestinalThoracic

Colonic Neoplasms, Glioblastoma, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Disease Progression

NCT07480941 2026-03-18

DUAL-CAR-NK-GB

Phase 1 Recruiting

Glioblastoma, Glioma

NCT04732065 2026-03-17

PNOC023

Phase 1 Recruiting

Ependymoma, Glioblastoma, Central Nervous System Neoplasms

NCT05109728 2026-03-16

A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.

Phase 1 Active not recruiting

Glioblastoma

NCT06186401 2026-03-16

Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells

Phase 1 Recruiting

Glioblastoma

NCT03749187 2026-03-13

PNOC017

Phase 1 Active not recruiting

Glioblastoma, Glioma

NCT06946680 2026-03-13

IMPACT

Phase 1 Active not recruiting

Brain Neoplasms, Glioblastoma, Glioma

NCT02287428 2026-03-12

Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM

Phase 1 Recruiting

Glioblastoma

NCT05743595 2026-03-11

Neoantigen-based Personalized DNA Vaccine With Retifanlimab PD-1 Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma

Phase 1 Active not recruiting

Glioblastoma

NCT04716699 2026-03-10

Systemic and Local Levels of Lidocaine During Surgery for the Removal of Glioblastoma

Phase 1 Completed

Glioblastoma

NCT05353530 2026-03-09

IMPACT

Phase 1 Active not recruiting

Brain Neoplasms, Glioblastoma

NCT06389591 2026-03-09

RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)

Phase 1 Active not recruiting

Brain Neoplasms, Glioblastoma

NCT07455045 2026-03-06

A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG)

Phase 1 Not yet recruiting

Glioblastoma, Glioma

NCT03896568 2026-03-05

MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

Phase 1 Recruiting

Astrocytoma, Glioblastoma, Glioma, Gliosarcoma

NCT04661384 2026-03-05

Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma

Phase 1 Active not recruiting

Ependymoma, Glioblastoma, Medulloblastoma, Meningeal Carcinomatosis

NCT06917885 2026-03-05

CUE-102 in Recurrent Glioblastoma

Phase 1 Recruiting

Glioblastoma, Glioma

NCT03152318 2026-03-04

rQNestin

Phase 1 Active not recruiting

Astrocytoma, Brain Neoplasms, Disease, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Ganglioglioma

NCT06665724 2026-02-27

Clinical Trial Evaluating Safety of 5-Aminolevulinic Acid (5-ALA) Combined With CV01 Delivery of Ultrasound for Sonodynamic Therapy (SDT) in Patients With Newly Diagnosed High-Grade Glioma (HGG) Prior to Resection and Standard Adjuvant Therapy (ALA SDT GLIOMA 401)

Phase 1 Completed

Astrocytoma, Glioblastoma, Oligodendroglioma

NCT02669173 2026-02-23

Capecitabine + Bevacizumab in Patients With Recurrent Glioblastoma

Phase 1 Completed

Brain Neoplasms, Glioblastoma, Recurrence

NCT03389802 2026-02-20

Phase I Study of APX005M in Pediatric Central Nervous System Tumors

Phase 1 Active not recruiting

32 enrolled 16 charts

Ependymoma, Glioblastoma, Medulloblastoma

NCT07422896 2026-02-20

Bvax

Phase 1 Not yet recruiting

Glioblastoma

NCT03514069 2026-02-19

Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma

Phase 1 Active not recruiting

Glioblastoma, Glioma

NCT05938387 2026-02-18

Safety and Tolerability of CVGBM in Adults With Newly Diagnosed MGMT-Unmethylated Glioblastoma or Astrocytoma

Phase 1 Completed

Glioblastoma

NCT04606316 2026-02-17

Surgical Nivolumab And Ipilimumab For Recurrent GBM

Phase 1 Active not recruiting

Glioblastoma

NCT05565118 2026-02-17

Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

Phase 1 Recruiting

Glioblastoma, Glioma

NCT07218367 2026-02-13

Phase I Trial of pH Resections of GBM at VA

Phase 1 Not yet recruiting

Glioblastoma, Glioma

NCT03681028 2026-02-12

Feasibility of Individualized Therapy for Recurrent Glioblastoma

Phase 1 Completed

Glioblastoma, Glioma