Clinical Trials Browser

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Leukoplakia, Neoplasms

NCT07210775 2026-03-04

Topical Imiquimod Treatment of Oral Dysplasia

Phase 1/2 Recruiting

20 enrolled

DermatologicHead & Neck

Leukoplakia, Leukokeratosis, Hereditary Mucosal

NCT05323292 2025-12-17

Vitamin A Status in Patients With Vocal Fold Leukoplakia

Enrolling by invitation

90 enrolled

Head & Neck

Leukoplakia, Vitamin A Deficiency

NCT00341497 2025-07-31

Biomarkers for Oral Cancer

Completed

80 enrolled

Head & Neck

Leukoplakia, Leukoplakia, Oral, Lichen Planus, Mouth Neoplasms

NCT03603223 2025-07-30

Pembrolizumab in Treating Participants With Leukoplakia

Phase 2 Recruiting

26 enrolled

Head & Neck

Leukoplakia

NCT06325514 2025-06-04

Artificial Intelligence Based Program to Classify Oral Cavity Findings Based on Clinical Image Analysis

Completed

241 enrolled

Head & Neck

Erythroplasia, Leukoedema, Oral, Leukoplakia, Mouth Neoplasms, Lichenoid Eruptions, Lichen Planus, Oral

NCT05536037 2025-05-15

Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions

Phase 1 Terminated

4 enrolled

Head & Neck

Erythroplasia, Leukoplakia, Mouth Neoplasms

NCT04622462 2024-11-07

Early Prediction of Oral Cancer by S100A7 Immunohistochemistry Signature-based Assessment

Recruiting

500 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Disease, Erythroplasia, Hyperplasia, Leukoplakia, Mouth Neoplasms, Keratoderma, Palmoplantar, Epidermolytic

NCT05853783 2024-11-07

Evaluation of Oral Potentially Malignant Disorders (OPMDs) with STRATICYTE™

Recruiting

180 enrolled

Head & Neck

Disease, Erythroplasia, Hyperplasia, Leukoplakia, Mouth Diseases, Keratoderma, Palmoplantar, Epidermolytic

NCT05296941 2023-09-08

PMOD

Phase NA Recruiting

200 enrolled

Head & Neck

Erythroplasia, Leukoplakia, Mouth Neoplasms, Lichen Planus, Oral

NCT04148651 2022-03-22

The CO2RE® System for Vulvar Lichen Sclerosus

Phase NA Completed

14 enrolled 12 charts

GynecologicHead & Neck

Vulvar Lichen Sclerosus, Leukoplakia, Keratoderma, Palmoplantar, Epidermolytic

NCT04267419 2020-02-13

Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions

Completed

100 enrolled

Head & Neck

Leukoplakia, Leukoplakia, Oral, Mouth Neoplasms, Lichen Planus, Oral

NCT03990636 2019-06-19

PDTMALAC

Phase 2 Unknown

40 enrolled

Head & Neck

Actinic cheilitis, Erythroplasia, Leukoplakia

NCT02321423 2018-11-21

IPCRR

Recruiting

2,000 enrolled

Head & Neck

Cysts, Leukoplakia, Pain, Pachyonychia Congenita

NCT00179361 2018-03-02

Natural History of Oro-pharyngeal Cancer Precursors

Completed

374 enrolled

Head & NeckOther neoplasm

Erythroplasia, Leukoplakia, Precancerous Conditions

NCT03233165 2017-07-28

Comparison Between Two Different High Power Ablative Lasers in the Treatment of Oral Leukoplakia

Phase NA Completed

54 enrolled

Head & Neck

Leukoplakia, Recurrence

NCT01497951 2017-05-17

PDT

Phase 3 Completed

28 enrolled

Head & Neck

Leukoplakia

NCT02737176 2016-08-01

TISOD

Phase NA Unknown

812 enrolled

DermatologicHead & Neck

Keratosis, Leukoplakia, Lichen Planus, Mouth Diseases, Periodontal Diseases, Smoking Cessation

NCT00571974 2015-03-24

Treatment of Oral Premalignant Lesions With 5-ALA PDT

Phase 1/2 Completed

29 enrolled 6 charts

Head & Neck

Erythroplasia, Leukoplakia

NCT00155337 2012-12-21

Photodynamic Therapy for Oral Leukoplakia and Erythroleukoplakia

Phase 4 Completed

40 enrolled

Head & Neck

Leukoplakia, Leukoplakia, Oral

NCT00001698 2008-03-04

Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR

Phase 2 Completed

57 enrolled

Head & Neck

Leukoplakia, Periodontal Diseases

Clinical Trials

H&NANCE

Topical Imiquimod Treatment of Oral Dysplasia

Vitamin A Status in Patients With Vocal Fold Leukoplakia

Biomarkers for Oral Cancer

Pembrolizumab in Treating Participants With Leukoplakia

Artificial Intelligence Based Program to Classify Oral Cavity Findings Based on Clinical Image Analysis

Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions

Early Prediction of Oral Cancer by S100A7 Immunohistochemistry Signature-based Assessment

Evaluation of Oral Potentially Malignant Disorders (OPMDs) with STRATICYTE™

PMOD

The CO2RE® System for Vulvar Lichen Sclerosus

Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions

PDTMALAC

IPCRR

Natural History of Oro-pharyngeal Cancer Precursors

Comparison Between Two Different High Power Ablative Lasers in the Treatment of Oral Leukoplakia

PDT

TISOD

Treatment of Oral Premalignant Lesions With 5-ALA PDT

Photodynamic Therapy for Oral Leukoplakia and Erythroleukoplakia

Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR