Clinical Trials Browser

Brain Neoplasms, Ependymoma, Medulloblastoma, Meningeal Neoplasms, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT05305365 2025-12-23

Study Assessing QBS72S For Treating Brain Metastases

Phase 2 Active not recruiting

21 enrolled

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms, Meningeal Neoplasms

NCT03423628 2025-12-22

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Phase 1 Recruiting

180 enrolled

CNS

Brain Neoplasms, Glioblastoma, Inhibition, Psychological, Meningeal Neoplasms, Hereditary Sensory and Autonomic Neuropathies

NCT04250545 2025-11-25

Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer

Phase 1 Active not recruiting

22 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Neoplasms

NCT05800275 2025-11-18

ETIC-LM

Phase 2 Recruiting

30 enrolled

CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT03501979 2025-08-29

Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD

Phase 2 Terminated

17 enrolled 16 charts

Breast

Breast Neoplasms, Meningeal Neoplasms

NCT05064306 2025-08-01

131I-omburtamab for the Treatment of Central Nervous System/Leptomeningeal Neoplasms in Children and Young Adults

No longer available

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Medulloblastoma, Meningeal Neoplasms, Wilms Tumor, Neuroblastoma, Pinealoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT07098806 2025-08-01

Meningeal Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Site, Nervous System Diseases, Nervous System Neoplasms, Pathologic Processes, Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT06933199 2025-05-04

NeoSTROBE

Phase NA Recruiting

260 enrolled

CNS

Brain Neoplasms, Meningeal Neoplasms

NCT05112549 2025-04-03

IT-PD1

Phase 1 Recruiting

46 enrolled

Meningeal Neoplasms

NCT05257967 2025-02-11

CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease

Phase NA Recruiting

10 enrolled

CNSThoracic

Carcinoma, Non-Small-Cell Lung, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT06417710 2024-05-16

NANO-LM

Recruiting

200 enrolled

CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT05414123 2023-10-16

FORESEE

Terminated

40 enrolled

BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT03613181 2023-04-24

ANGLeD

Phase 3 Unknown

150 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT03711422 2022-06-14

Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC

Phase 1 Terminated

2 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung, Meningeal Neoplasms

NCT00062881 2020-03-04

Intrathecal Mafosfamide

Phase 1 Completed

65 enrolled

LymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Meningeal Neoplasms, Neoplasms

NCT01596127 2018-05-24

Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System

Phase 1/2 Terminated

4 enrolled 7 charts

CNSOther hematologic neoplasm

Central Nervous System Diseases, Leukemia, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00512460 2016-05-16

RTA 744 Injection in Patients With Leptomeningeal Disease

Phase 1 Terminated

7 enrolled

CNSLymphoidOther hematologic neoplasm

Brain Neoplasms, Leukemia, Lymphoma, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00890435 2015-10-21

Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial

Completed

53 enrolled

CNSLymphoidOther hematologic neoplasm

Familial ependymoma, Congenital Abnormalities, Astrocytoma, Brain Neoplasms, Craniopharyngioma, Glioma, Leukemia, Leukemia, Hairy Cell, Leukemia, Mast-Cell, Medulloblastoma, Meningeal Neoplasms, Meningioma, Oligodendroglioma, Pinealoma, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Biphenotypic, Acute, Leukemia, Prolymphocytic, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Optic Nerve Glioma, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myelomonocytic, Juvenile, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative

NCT00757614 2013-08-26

Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom

Unknown

14,000 enrolled

CNSDermatologicGastrointestinalGenitourinaryLymphoidOther hematologic neoplasm

Uveal Melanoma, Astrocytoma, Urinary Bladder Neoplasms, Brain Neoplasms, Carcinoma, Renal Cell, Craniopharyngioma, Esophageal Neoplasms, Hodgkin Disease, Kidney Neoplasms, Lymphoma, Lymphoma, Non-Hodgkin, Melanoma, Meningeal Neoplasms, Neoplasms, Germ Cell and Embryonal, Pancreatic Neoplasms, Pinealoma, Lymphoma, T-Cell, Cutaneous, Lymphoma, AIDS-Related, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Nephroma, Mesoblastic, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Intraocular Lymphoma

NCT00001251 2013-08-19

Phase I Study of Intrathecal Mafosfamide

Phase 1 Completed

65 enrolled

LymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Meningeal Neoplasms

NCT00515788 2012-03-12

DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis

Phase 1 Terminated

11 enrolled

CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00001333 2008-03-04

Phase I Study of Intrathecal Topotecan

Phase 1 Completed

30 enrolled

LymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Meningeal Neoplasms

NCT00029523 2007-02-28

DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor

Phase 4 Completed

100 enrolled

Meningeal Neoplasms, Meningitis

Clinical Trials

Optimizing Contrast Dose and Scanning Parameters for Detection of Leptomeningeal Disease

Non Interventional German Leptomeningeal Disease Register

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV)

Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis

Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma

CSF and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and CNS Metastases or no CNS Metastases

TUXEDO-3

Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology

Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study

Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease

B7-H3.CD28Z.CART in CNS Neoplasms

Study Assessing QBS72S For Treating Brain Metastases

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer

ETIC-LM

Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD

131I-omburtamab for the Treatment of Central Nervous System/Leptomeningeal Neoplasms in Children and Young Adults

CA2024-LM-001

NeoSTROBE

IT-PD1

CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease

NANO-LM

FORESEE

ANGLeD

Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC

Intrathecal Mafosfamide

Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System

RTA 744 Injection in Patients With Leptomeningeal Disease

Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial

Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom

Phase I Study of Intrathecal Mafosfamide

DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis

Phase I Study of Intrathecal Topotecan

DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor