Clinical Trials Browser

Phase 1 × Meningeal Neoplasms × Clear all

NCT04250545 2026-05-26

Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer

Phase 1 Active not recruiting

22 enrolled 14 charts

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Neoplasms

NCT05809752 2026-05-11

A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV)

Phase 1 Active not recruiting

Meningeal Neoplasms, Triple Negative Breast Neoplasms

NCT03025256 2026-05-05

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

Phase 1 Recruiting

DermatologicThoracic

Uveal Melanoma, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Melanoma, Meningeal Neoplasms, Nevus

NCT03719768 2026-03-02

Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

Phase 1 Completed

Brain Neoplasms, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT07390539 2026-02-05

B7-H3.CD28Z.CART in CNS Neoplasms

Phase 1 Not yet recruiting

Brain Neoplasms, Ependymoma, Medulloblastoma, Meningeal Neoplasms, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT03423628 2025-12-22

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Phase 1 Recruiting

Brain Neoplasms, Glioblastoma, Inhibition, Psychological, Meningeal Neoplasms, Hereditary Sensory and Autonomic Neuropathies

NCT07098806 2025-08-01

CA2024-LM-001

Phase 1 Recruiting

Meningeal Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Site, Nervous System Diseases, Nervous System Neoplasms, Pathologic Processes, Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT05112549 2025-04-03

IT-PD1

Phase 1 Recruiting

Meningeal Neoplasms

NCT03711422 2022-06-14

Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC

Phase 1 Terminated

Carcinoma, Non-Small-Cell Lung, Meningeal Neoplasms

NCT00062881 2020-03-04

Intrathecal Mafosfamide

Phase 1 Completed

LymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Meningeal Neoplasms, Neoplasms

NCT00512460 2016-05-16

RTA 744 Injection in Patients With Leptomeningeal Disease

Phase 1 Terminated

CNSLymphoidOther hematologic neoplasm

Brain Neoplasms, Leukemia, Lymphoma, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00001251 2013-08-19

Phase I Study of Intrathecal Mafosfamide

Phase 1 Completed

LymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Meningeal Neoplasms

NCT00515788 2012-03-12

DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis

Phase 1 Terminated

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00001333 2008-03-04

Phase I Study of Intrathecal Topotecan

Phase 1 Completed

LymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Meningeal Neoplasms