Announcements Trials
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Phase

Phase 1 3Phase 2 1Phase 1/2 1

Status

Recruiting 13Completed 7Terminated 6Active not recruiting 5Unknown 2Not yet recruiting 2No longer available 1

Sponsor Class

OTHER 5INDUSTRY 1

Study Type

Interventional 5Observational 1

Sponsor

Cancer Type

CNS 4Thoracic 2Other hematologic neoplasm 2Breast 2Lymphoid 1

Conditions

Breast Neoplasms 1127Neoplasms 982Carcinoma, Non-Small-Cell Lung 900Prostatic Neoplasms 594Neoplasm Metastasis 528Leukemia, Myeloid, Acute 513Colorectal Neoplasms 491Lung Neoplasms 487Melanoma 485Multiple Myeloma 477Pancreatic Neoplasms 385Lymphoma 369Ovarian Neoplasms 368Recurrence 365Lymphoma, Non-Hodgkin 346Leukemia 339Leukemia, Lymphocytic, Chronic, B-Cell 321Precursor Cell Lymphoblastic Leukemia-Lymphoma 291Head and Neck Neoplasms 276Carcinoma, Renal Cell 276Brain Neoplasms 273Carcinoma, Hepatocellular 261Glioblastoma 249Lymphoma, Large B-Cell, Diffuse 244Myelodysplastic Syndromes 242Squamous Cell Carcinoma of Head and Neck 241Lymphoma, Follicular 236Colonic Neoplasms 214Stomach Neoplasms 200Rectal Neoplasms 190

Interventions

tucatinib 1WP 744 1Trastuzumab 1Temozolomide 1Rituximab 1Capecitabine 1Afatinib 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

6 trials
RecentStart dateEnrollment
Terminated × Meningeal Neoplasms × Clear all
NCT03501979 2025-08-29

Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD

University of Alabama at Birmingham

Phase 2 Terminated
17 enrolled 16 charts
Breast

Breast Neoplasms, Meningeal Neoplasms

NCT05414123 2023-10-16

FORESEE

Biocept, Inc.

Terminated
40 enrolled
BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT03711422 2022-06-14

Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC

National Cancer Centre, Singapore

Phase 1 Terminated
2 enrolled
Thoracic

Carcinoma, Non-Small-Cell Lung, Meningeal Neoplasms

NCT01596127 2018-05-24

Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System

M.D. Anderson Cancer Center

Phase 1/2 Terminated
4 enrolled 7 charts
CNSOther hematologic neoplasm

Central Nervous System Diseases, Leukemia, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00512460 2016-05-16

RTA 744 Injection in Patients With Leptomeningeal Disease

M.D. Anderson Cancer Center

Phase 1 Terminated
7 enrolled
CNSLymphoidOther hematologic neoplasm

Brain Neoplasms, Leukemia, Lymphoma, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00515788 2012-03-12

DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis

M.D. Anderson Cancer Center

Phase 1 Terminated
11 enrolled
CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

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