Clinical Trials Browser

Interventional × Meningeal Neoplasms × Clear all

NCT07415018 2026-04-14

Optimizing Contrast Dose and Scanning Parameters for Detection of Leptomeningeal Disease

Phase NA Not yet recruiting

Meningeal Neoplasms

NCT03025256 2026-04-02

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

Phase 1 Recruiting

DermatologicThoracic

Uveal Melanoma, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Melanoma, Meningeal Neoplasms, Nevus

NCT05809752 2026-04-01

A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV)

Phase 1 Recruiting

Meningeal Neoplasms, Triple Negative Breast Neoplasms

NCT02422641 2026-03-23

Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis

Phase 2 Recruiting

Breast Neoplasms, Meningeal Neoplasms

NCT00338377 2026-03-20

Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma

Phase 2 Active not recruiting

Melanoma, Meningeal Neoplasms

NCT07476781 2026-03-17

CSF and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and CNS Metastases or no CNS Metastases

Phase NA Recruiting

Meningeal Neoplasms

NCT05865990 2026-03-12

TUXEDO-3

Phase 2 Active not recruiting

Brain Neoplasms, Breast Neoplasms, Meningeal Neoplasms

NCT03719768 2026-03-02

Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

Phase 1 Completed

Brain Neoplasms, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT06016387 2026-02-23

Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study

Phase 2 Recruiting

Breast Neoplasms, Meningeal Neoplasms

NCT04588545 2026-02-09

Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease

Phase 1/2 Recruiting

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT07390539 2026-02-05

B7-H3.CD28Z.CART in CNS Neoplasms

Phase 1 Not yet recruiting

Brain Neoplasms, Ependymoma, Medulloblastoma, Meningeal Neoplasms, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT05305365 2025-12-23

Study Assessing QBS72S For Treating Brain Metastases

Phase 2 Active not recruiting

BreastCNSThoracic

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms, Meningeal Neoplasms

NCT03423628 2025-12-22

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Phase 1 Recruiting

Brain Neoplasms, Glioblastoma, Inhibition, Psychological, Meningeal Neoplasms, Hereditary Sensory and Autonomic Neuropathies

NCT04250545 2025-11-25

Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer

Phase 1 Active not recruiting

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Neoplasms

NCT05800275 2025-11-18

ETIC-LM

Phase 2 Recruiting

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT03501979 2025-08-29

Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD

Phase 2 Terminated

17 enrolled 16 charts

Breast Neoplasms, Meningeal Neoplasms

NCT07098806 2025-08-01

CA2024-LM-001

Phase 1 Recruiting

Meningeal Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Site, Nervous System Diseases, Nervous System Neoplasms, Pathologic Processes, Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT06933199 2025-05-04

NeoSTROBE

Phase NA Recruiting

Brain Neoplasms, Meningeal Neoplasms

NCT05112549 2025-04-03

IT-PD1

Phase 1 Recruiting

Meningeal Neoplasms

NCT05257967 2025-02-11

CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease

Phase NA Recruiting

Carcinoma, Non-Small-Cell Lung, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT03613181 2023-04-24

ANGLeD

Phase 3 Unknown

Brain Neoplasms, Breast Neoplasms, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT03711422 2022-06-14

Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC

Phase 1 Terminated

Carcinoma, Non-Small-Cell Lung, Meningeal Neoplasms

NCT00062881 2020-03-04

Intrathecal Mafosfamide

Phase 1 Completed

LymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Meningeal Neoplasms, Neoplasms

NCT01596127 2018-05-24

Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System

Phase 1/2 Terminated

4 enrolled 7 charts

CNSOther hematologic neoplasm

Central Nervous System Diseases, Leukemia, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00512460 2016-05-16

RTA 744 Injection in Patients With Leptomeningeal Disease

Phase 1 Terminated

CNSLymphoidOther hematologic neoplasm

Brain Neoplasms, Leukemia, Lymphoma, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00001251 2013-08-19

Phase I Study of Intrathecal Mafosfamide

Phase 1 Completed

LymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Meningeal Neoplasms

NCT00515788 2012-03-12

DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis

Phase 1 Terminated

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00001333 2008-03-04

Phase I Study of Intrathecal Topotecan

Phase 1 Completed

LymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Meningeal Neoplasms

NCT00029523 2007-02-28

DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor

Phase 4 Completed

Meningeal Neoplasms, Meningitis