Clinical Trials

Phase 2 Not yet recruiting

Mesothelioma, Malignant, Pleural Effusion, Malignant

NCT02122185 2026-03-27

Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Phase 2 Completed

111 enrolled 15 charts

GynecologicThoracic

Carcinoma, Ovarian Epithelial, Brenner Tumor, Fallopian Tube Neoplasms, Pleural Effusion, Malignant

NCT07482605 2026-03-20

Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion

63 enrolled

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Pleural Effusion, Malignant

NCT06436807 2026-03-12

PMCF Study of the CE-marked Drainova® ArgentiC Catheter

169 enrolled

Ascites, Pleural Effusion, Pleural Effusion, Malignant

NCT07192900 2026-01-15

(RIOT 4A)

Mesothelioma, Malignant, Pleural Effusion, Malignant

NCT07167992 2026-01-06

Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis

160 enrolled

Phase 3 Active not recruiting

Pneumothorax, Pleural Effusion, Malignant

NCT04914598 2026-01-02

A Phase Ⅲ Clinical Study of Combined Cisplatin Versus Placebo Combined With Intracavitary Cisplatin Injection in the Treatment of Malignant Pleural Effusions

290 enrolled

Pleural Effusion, Malignant

NCT07208409 2025-12-24

Pleurodesis in Small-bore Chest Tube

60 enrolled

Pleural Effusion, Malignant

NCT02092155 2025-12-17

BLAST

Enrolling by invitation

95 enrolled

Pleural Effusion, Malignant

NCT02649894 2025-12-11

SWIFT

Phase NA Completed

119 enrolled 16 charts

Pleural Effusion, Malignant

NCT02227732 2025-11-26

A Pilot Study Evaluating the Safety and Effectiveness of a New Pleural Catheter for the Medical Management of Symptomatic, Recurrent, Malignant Pleural Effusions

Phase NA Completed

Pleural Effusion, Malignant

NCT05620329 2025-10-16

UNC Pleural Fluid Registry

Recruiting

9,999 enrolled

BreastThoracic

Breast Neoplasms, Empyema, Infections, Lung Neoplasms, Neoplasms, Pleural Effusion, Malignant

NCT03235999 2025-10-03

The Experiences of Patients Living With Malignant Pleural Effusions

Pleural Effusion, Malignant

NCT07147270 2025-08-29

Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound

30 enrolled

Pleural Effusion, Malignant

NCT07120867 2025-08-13

Impact of Pleural Manometry on the Assessment and Treatment of Malignant Pleural Effusion: A Pilot Clinical Trial

95 enrolled

Phase NA Active not recruiting

Myeloproliferative Disorder, Chronic, with Eosinophilia, Pleural Effusion, Malignant

NCT06210685 2025-08-11

The ACES Study for Aseptic Pleural Effusion

25 enrolled

Pleural Effusion, Pleural Effusion, Malignant

NCT06657638 2025-05-29

Cytological Examination of Malignant Pleural Effusion in Breast Cancer

50 enrolled

BreastThoracic

Breast Neoplasms, Pleural Effusion, Malignant

NCT06016179 2025-05-22

RIOT2

12 enrolled

Pleural Effusion, Malignant

NCT06964321 2025-05-09

Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Management of Massive Malignant Pleural Effusion

66 enrolled

Pleural Effusion, Malignant

NCT06959719 2025-05-07

ARMSTRONG

41 enrolled

Myeloproliferative Disorder, Chronic, with Eosinophilia, Pleural Effusion, Pleural Effusion, Malignant

NCT06946498 2025-04-27

FLAT

100 enrolled

Mesothelioma, Malignant, Lung Neoplasms, Mesothelioma, Pleural Effusion, Pleural Effusion, Malignant

NCT06740019 2025-04-04

A Phase Ib Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion

30 enrolled

Myeloproliferative Disorder, Chronic, with Eosinophilia, Pleural Effusion, Malignant

NCT04669223 2025-03-28

Comparing Different Sizes of Small-bore Chest Drains in Malignant Pleural Effusion

Phase NA Terminated

52 enrolled

Lung Neoplasms, Pleural Effusion, Malignant

NCT06744946 2024-12-20

Thoracoscopic Talc Pleurodesis Versus Bleomycin -Tranxemic Acid Mixture Injection in Chest Tube in Malignant Pleural Effusion

Phase 4 Completed

60 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Pleural Effusion, Malignant

NCT06742099 2024-12-19

The Outcome of Inserting Intercostal Tube or Pleurodesis for Malignant Pleural Effusion

20 enrolled

Myeloproliferative Disorder, Chronic, with Eosinophilia, Pleural Effusion, Malignant

NCT06729931 2024-12-12

Quantitative C-Reactive Protein for Differentiating Tuberculous and Malignant Pleural Effusion: a Cross-Sectional Study

81 enrolled

Pleural Effusion, Pleural Effusion, Malignant

NCT06726564 2024-12-10

A Study of MT027 in Patients with Pleural Malignant Tumors

18 enrolled

BreastEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Mesothelioma, Malignant, Neoplasm Metastasis, Pleural Effusion, Malignant

NCT04985357 2024-11-25

Defining the Clinical Potential of Mass Response As a Biomarker for Patient Tumor Sensitivity to Drugs

Withdrawn

Anus Neoplasms, Appendiceal Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Laryngeal Neoplasms, Lip Neoplasms, Lung Neoplasms, Mesothelioma, Mouth Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Paranasal Sinus Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Thymoma, Vulvar Neoplasms, Pleural Effusion, Malignant, Carcinoma, Neuroendocrine, Cholangiocarcinoma, Carcinoma, Ductal, Small Cell Lung Carcinoma

NCT06691009 2024-11-15

Pleural Bleomycin vs Mechanical Abrasion in Malignant Pleural Effusion

70 enrolled

Pleural Effusion, Malignant

NCT06682936 2024-11-12

Feasibility of Ambulatory Talc. Pleurodesis

15 enrolled

Phase EARLY_PHASE1 Recruiting

Neoplasms, Pleural Effusion, Malignant

NCT04684459 2024-10-30

Dual-targeting HER2 and PD-L1 CAR-T for Solid Tumors

18 enrolled

Pleural Effusion, Malignant

NCT00791154 2024-08-23

SCLC

Phase 1/2 Terminated

213 enrolled 16 charts

Lung Neoplasms, Pleural Effusion, Malignant, Small Cell Lung Carcinoma

NCT06512896 2024-07-22

Clinical Study on Intraluminal Injection of FOLactis

40 enrolled

Pleural Effusion, Malignant

NCT06421610 2024-05-20

OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion.

20 enrolled

Pleural Effusion, Pleural Neoplasms, Pleural Effusion, Malignant

NCT05268172 2024-05-16

IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and Ascites

40 enrolled

Pleural Effusion, Malignant

NCT06275178 2024-02-23

Medical Thoracoscopy for Diagnosing Unexplained Pleural Effusion: a National Multicenter Retrospective Study

Unknown

5,000 enrolled

Pleural Effusion, Pleural Effusion, Malignant

NCT03414905 2024-02-20

Management of Malignant Pleural Effusions Using an Indwelling Tunneled Pleural Catheter and Non-Vacuum Collection System

40 enrolled

MyeloidOther solid neoplasmThoracic

Pleural Effusion, Malignant

NCT05375825 2024-02-02

Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin

Phase 1 Withdrawn

Myeloproliferative Disorder, Chronic, with Eosinophilia, Mesothelioma, Malignant, Carcinoma, Pleural Effusion, Malignant

NCT05278975 2024-01-26

Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma

Phase 1/2 Unknown

186 enrolled

Mesothelioma, Malignant, Mesothelioma, Pleural Effusion, Malignant

NCT02517749 2023-11-24

OPTIMUM

Phase NA Completed

142 enrolled

Pleural Effusion, Malignant

NCT05291403 2023-11-18

Efficacy and Safety Study of Medical Thoracoscope Cryotherapy Combined Standard First-line Treatment of Advanced Non-small Cell Lung Cancer and Malignant Pleural Effusion

Phase NA Unknown

141 enrolled

Carcinoma, Non-Small-Cell Lung, Pleural Effusion, Malignant

NCT04792970 2023-09-28

Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusion

Phase 4 Terminated

4 enrolled 14 charts