Clinical Trials

Myeloproliferative Disorder, Chronic, with Eosinophilia, Carcinoma, Non-Small-Cell Lung, Pleural Effusion, Malignant

NCT05543330 2026-05-14

A Phase Ib/II Clinical Trial of M701 in the Treatment of Malignant Pleural Effusions Caused by NSCLC

Phase 1/2 Recruiting

96 enrolled

Carcinoma, Non-Small-Cell Lung, Pleural Effusion, Malignant

NCT04322136 2026-05-05

AMPLE-3

158 enrolled

Phase 2 Active not recruiting

Neoplasms, Respiration Disorders, Pleural Effusion, Malignant

NCT00761618 2026-04-16

Intrapleural Catheter Daily Versus Three Times a Week Drainage

257 enrolled

Pleural Effusion, Pleural Effusion, Malignant

NCT07443020 2026-04-07

RIOT 4B

10 enrolled

Mesothelioma, Malignant, Pleural Effusion, Malignant

NCT02122185 2026-03-27

Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Phase 2 Not yet recruiting

111 enrolled 15 charts

GynecologicThoracic

Carcinoma, Ovarian Epithelial, Brenner Tumor, Fallopian Tube Neoplasms, Pleural Effusion, Malignant

NCT07482605 2026-03-20

Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion

63 enrolled

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Pleural Effusion, Malignant

NCT07192900 2026-01-15

(RIOT 4A)

10 enrolled

Mesothelioma, Malignant, Pleural Effusion, Malignant

NCT07167992 2026-01-06

Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis

160 enrolled

Phase 3 Active not recruiting

Pneumothorax, Pleural Effusion, Malignant

NCT04914598 2026-01-02

A Phase Ⅲ Clinical Study of Combined Cisplatin Versus Placebo Combined With Intracavitary Cisplatin Injection in the Treatment of Malignant Pleural Effusions

290 enrolled

Pleural Effusion, Malignant

NCT07208409 2025-12-24

Pleurodesis in Small-bore Chest Tube

60 enrolled

Pleural Effusion, Malignant

NCT02649894 2025-12-11

SWIFT

119 enrolled 16 charts

Pleural Effusion, Malignant

NCT02227732 2025-11-26

A Pilot Study Evaluating the Safety and Effectiveness of a New Pleural Catheter for the Medical Management of Symptomatic, Recurrent, Malignant Pleural Effusions

10 enrolled

Pleural Effusion, Malignant

NCT07147270 2025-08-29

Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound

30 enrolled

Pleural Effusion, Malignant

NCT07120867 2025-08-13

Impact of Pleural Manometry on the Assessment and Treatment of Malignant Pleural Effusion: A Pilot Clinical Trial

95 enrolled

Phase NA Active not recruiting

Myeloproliferative Disorder, Chronic, with Eosinophilia, Pleural Effusion, Malignant

NCT06210685 2025-08-11

The ACES Study for Aseptic Pleural Effusion

25 enrolled

Pleural Effusion, Pleural Effusion, Malignant

NCT06016179 2025-05-22

RIOT2

12 enrolled

Pleural Effusion, Malignant

NCT06964321 2025-05-09

Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Management of Massive Malignant Pleural Effusion

66 enrolled

Pleural Effusion, Malignant

NCT06959719 2025-05-07

ARMSTRONG

41 enrolled

Myeloproliferative Disorder, Chronic, with Eosinophilia, Pleural Effusion, Pleural Effusion, Malignant

NCT06946498 2025-04-27

FLAT

Mesothelioma, Malignant, Lung Neoplasms, Mesothelioma, Pleural Effusion, Pleural Effusion, Malignant

NCT06740019 2025-04-04

A Phase Ib Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion

30 enrolled

Myeloproliferative Disorder, Chronic, with Eosinophilia, Pleural Effusion, Malignant

NCT04669223 2025-03-28

Comparing Different Sizes of Small-bore Chest Drains in Malignant Pleural Effusion

Phase NA Terminated

52 enrolled

Lung Neoplasms, Pleural Effusion, Malignant

NCT06744946 2024-12-20

Thoracoscopic Talc Pleurodesis Versus Bleomycin -Tranxemic Acid Mixture Injection in Chest Tube in Malignant Pleural Effusion

Phase 4 Completed

60 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Pleural Effusion, Malignant

NCT06742099 2024-12-19

The Outcome of Inserting Intercostal Tube or Pleurodesis for Malignant Pleural Effusion

20 enrolled

Myeloproliferative Disorder, Chronic, with Eosinophilia, Pleural Effusion, Malignant

NCT06726564 2024-12-10

A Study of MT027 in Patients with Pleural Malignant Tumors

18 enrolled

Mesothelioma, Malignant, Neoplasm Metastasis, Pleural Effusion, Malignant

NCT06691009 2024-11-15

Pleural Bleomycin vs Mechanical Abrasion in Malignant Pleural Effusion

70 enrolled

Pleural Effusion, Malignant

NCT06682936 2024-11-12

Feasibility of Ambulatory Talc. Pleurodesis

15 enrolled

Phase EARLY_PHASE1 Recruiting

Neoplasms, Pleural Effusion, Malignant

NCT04684459 2024-10-30

Dual-targeting HER2 and PD-L1 CAR-T for Solid Tumors

18 enrolled

Pleural Effusion, Malignant

NCT00791154 2024-08-23

SCLC

Phase 1/2 Terminated

213 enrolled 16 charts

Lung Neoplasms, Pleural Effusion, Malignant, Small Cell Lung Carcinoma

NCT06512896 2024-07-22

Clinical Study on Intraluminal Injection of FOLactis

40 enrolled

Pleural Effusion, Malignant

NCT06421610 2024-05-20

OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion.

20 enrolled

Pleural Effusion, Pleural Neoplasms, Pleural Effusion, Malignant

NCT05268172 2024-05-16

IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and Ascites

40 enrolled

MyeloidOther solid neoplasmThoracic

Pleural Effusion, Malignant

NCT05375825 2024-02-02

Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin

Phase 1 Withdrawn

Myeloproliferative Disorder, Chronic, with Eosinophilia, Mesothelioma, Malignant, Carcinoma, Pleural Effusion, Malignant

NCT05278975 2024-01-26

Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma

Phase 1/2 Unknown

186 enrolled

Mesothelioma, Malignant, Mesothelioma, Pleural Effusion, Malignant

NCT02517749 2023-11-24

OPTIMUM

142 enrolled

Pleural Effusion, Malignant

NCT05291403 2023-11-18

Efficacy and Safety Study of Medical Thoracoscope Cryotherapy Combined Standard First-line Treatment of Advanced Non-small Cell Lung Cancer and Malignant Pleural Effusion

141 enrolled

Carcinoma, Non-Small-Cell Lung, Pleural Effusion, Malignant

NCT04792970 2023-09-28

Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusion

Phase 4 Terminated

4 enrolled 14 charts

Pleural Effusion, Malignant

NCT00993655 2023-08-28

Intraperitoneal vs Intravenous Chemotherapy Following Neoadjuvant Chemotherapy in Ovarian Cancer

BreastGynecologicOther solid neoplasmThoracic

275 enrolled 13 charts

GynecologicThoracic

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Pleural Effusion, Malignant

NCT01997190 2023-08-25

MpeTK01

Phase 1 Completed

19 enrolled

Breast Neoplasms, Lung Neoplasms, Mesothelioma, Ovarian Neoplasms, Pleural Effusion, Malignant

NCT05923515 2023-06-28

A Phase I Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion

Phase 1 Unknown

78 enrolled

Pleural Effusion, Malignant

NCT00002872 2023-06-22

Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions

Phase 3 Completed

480 enrolled

Neoplasm Metastasis, Pleural Effusion, Malignant

NCT05872126 2023-05-24

Video Assisted Thoracoscopic Surgery (VATS) - Surgical Pleurodesis vs Tube Drainage in Management of Malignant Pleural Effusion (MPE)

60 enrolled

Pleural Effusion, Malignant

NCT03449602 2023-03-29

MICRO

Lung Neoplasms, Neoplasm Metastasis, Pleural Effusion, Tuberculosis, Pleural Effusion, Malignant

NCT04749602 2023-03-08

Intrapleural Instillation of the Nivolumab in Cancer Patients With Pleural Effusion.

26 enrolled

Classical hematologyThoracic

Pleural Effusion, Malignant

NCT00858364 2022-11-30

Anemia Treatment for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy

Phase 3 Terminated

2,549 enrolled 19 charts

Anemia, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms, Pleural Effusion, Pleural Effusion, Malignant

NCT02583282 2022-10-06

A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleurodesis in Malignant Pleural Effusion

Phase EARLY_PHASE1 Unknown

Pleural Effusion, Malignant

NCT05565014 2022-10-04

Safety and Efficacy Study of Virus Activated Killer Immune Cells (VAK) for Malignant Pleural and Peritoneal Effusion

90 enrolled

Pleural Effusion, Malignant

NCT00637676 2022-09-02

Tunneled Pleural Catheter in Partially Entrapped Lung

50 enrolled

Pleural Effusion, Malignant

NCT04806412 2022-05-17

Oncodrivers in Malignant Pleural Effusions Associated With Non-small Cell Lung Cancer: A Prospective Study.