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Clinical Trials

8 trials
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Phase

Phase 2 4Phase 1 3Phase 1/2 1

Status

Completed 4Active not recruiting 2Withdrawn 1Terminated 1

Sponsor Class

OTHER 6INDUSTRY 2

Study Type

Interventional 8

Sponsor

Cancer Type

Head & Neck 4Gastrointestinal 2Thoracic 1Gynecologic 1Genitourinary 1Breast 1

Conditions

Squamous Cell Carcinoma of Head and Neck 4Head and Neck Neoplasms 2Uterine Cervical Dysplasia 1Recurrence 1Neoplasms 1Neoplasm Metastasis 1Mouth Neoplasms 1Clinical Stage IV Gastric Cancer AJCC v8 1Carcinoma, Transitional Cell 1Carcinoma, Squamous Cell 1Carcinoma, Renal Cell 1Carcinoma, Non-Small-Cell Lung 1Carcinoma, Hepatocellular 1Breast Neoplasms 1

Interventions

Cisplatin 3176Cyclophosphamide 3172Carboplatin 2955Radiotherapy 2771Paclitaxel 2705Gemcitabine 2549pembrolizumab 2368Bevacizumab 2192Docetaxel 2190Fluorouracil 1837Capecitabine 1815Oxaliplatin 1723Dexamethasone 1592Nivolumab 1575Doxorubicin 1500Rituximab 1480Magnetic Resonance Spectroscopy 1365Etoposide 1341Irinotecan 1240Leucovorin 1215Drug Therapy 1189Cytarabine 1126Pemetrexed 1067fludarabine 1035Specimen Handling 985Vincristine 964Prednisone 940Cetuximab 938Trastuzumab 936Lenalidomide 932

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements
NCT04373031 2025-12-02

Pembrolizumab, IRX-2, and Chemotherapy in Triple Negative Breast Cancer

Providence Health & Services

Phase 2 Active not recruiting
12 enrolled 11 charts
Breast

Breast Neoplasms

NCT03655002 2025-06-17

IRX-2, Cyclophosphamide, and Nivolumab in Treating Patients With Recurrent or Metastatic and Refractory Liver Cancer

City of Hope Medical Center

Phase 1 Active not recruiting
8 enrolled
Gastrointestinal

Carcinoma, Hepatocellular

NCT03267680 2025-04-13

IRX-2 Regimen in Treating Women With Cervical Squamous Intraepithelial Neoplasia 3 or Squamous Vulvar Intraepithelial Neoplasia 3

University of Southern California

Phase 2 Terminated
10 enrolled 19 charts
Gynecologic

Uterine Cervical Dysplasia

NCT02609386 2024-01-30

INSPIRE

Brooklyn ImmunoTherapeutics, LLC

Phase 2 Completed
105 enrolled 17 charts
Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms

NCT03758781 2023-04-14

IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors

H. Lee Moffitt Cancer Center and Research Institute

Phase 1 Completed
12 enrolled
GenitourinaryHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Neoplasm Metastasis, Recurrence

NCT03918499 2023-03-23

IRX-2, Cyclophosphamide, and Pembrolizumab in Treating Participants With Recurrent or Metastatic Gastric or Gastroesophageal Junction Cancer

City of Hope Medical Center

Phase 1/2 Completed
9 enrolled 9 charts
Gastrointestinal

Clinical Stage IV Gastric Cancer AJCC v8

NCT00210470 2020-12-11

A Phase 2 Clinical Trial of the Safety and Effects of IRX-2 in Treating Patients With Operable Head and Neck Cancer

Brooklyn ImmunoTherapeutics, LLC

Phase 2 Completed
27 enrolled 16 charts
Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Mouth Neoplasms

NCT03575234 2019-08-28

Nivolumab & IRX-2 With Surgery for Resectable Stage III-IVA Oral Cavity Cancer or HPV-Positive Oropharyngeal Cancer

Emory University

Phase 1 Withdrawn
Head & Neck

Squamous Cell Carcinoma of Head and Neck

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