Clinical Trials
64 trialsNCT02968810 2026-05-04
Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis
National Cancer Institute (NCI)
Phase 2 Active not recruiting
NCT05821556 2026-04-14
Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma Patients
National Cancer Institute, Naples
Phase 2 Recruiting
NCT07392541 2026-03-23
Adebrelimab Combined With Gemcitabine, Cisplatin, and Simvastatin for Advanced Biliary Tract Cancer
Tongji Hospital
Phase 1/2 Recruiting
NCT05586360 2026-03-04
T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate Cancer
Medical University of South Carolina
Phase 2 Recruiting
NCT04457089 2026-02-04
Statin Therapy to Reduce Progression in Women With Platinum Sensitive Ovarian Cancer
Cedars-Sinai Medical Center
Phase EARLY_PHASE1 Completed
NCT04514029 2026-01-08
Neurotoxicity Prophylaxis With Intrathecal Dexamethasone and Simvastatin Post Axi-Cel
Masonic Cancer Center, University of Minnesota
Phase EARLY_PHASE1 Active not recruiting
NCT03654053 2026-01-07
SACRED
VA Office of Research and Development
Phase 3 Active not recruiting
NCT02197234 2025-11-20
Study to Assess the Effect of AZD9291 on the Blood Levels of Simvastatin in Patients With EGFRm+ NSCLC
AstraZeneca
Phase 1 Completed
NCT03889795 2025-10-20
Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors
University of Toledo
Phase 1 Active not recruiting
NCT03400826 2025-07-14
Effects of Simvastatin on Uterine Leiomyoma Size
Johns Hopkins University
Phase 2 Recruiting
NCT07003815 2025-06-04
Envafolimab With Chemotherapy and Simvastatin in Advanced Biliary Tract Cancer
Tongji Hospital
Phase 2 Not yet recruiting
NCT05464810 2025-05-23
Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer
Emory University
Phase EARLY_PHASE1 Recruiting
NCT03324425 2025-02-27
SIMPHONY
Baylor Breast Care Center
Phase 2 Active not recruiting
NCT03127631 2025-01-31
RADICALPC
McMaster University
Phase NA Recruiting
NCT05550415 2024-10-03
The Role of Simvastatin in the Epithelial-Mesenchymal Transition Process of Breast Cancer
Indonesia University
Phase 2 Recruiting
NCT02096588 2024-07-09
Detection and Prevention of Anthracycline-Related Cardiac Toxicity With Concurrent Simvastatin
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Phase 2 Terminated
NCT06030622 2024-04-19
C3
State University of New York - Downstate Medical Center
Phase 1/2 Unknown
NCT01764451 2024-03-12
Permeability MRI in Cerebral Cavernous Malformations Type 1 in New Mexico: Effects of Statins
University of New Mexico
Phase EARLY_PHASE1 Terminated
NCT03454529 2023-08-01
The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast Cancer
Barbara Ann Karmanos Cancer Institute
Phase 2 Completed
NCT02534376 2023-02-22
Cellular Effect of Cholesterol-Lowering Prior to Prostate Removal
Cedars-Sinai Medical Center
Phase EARLY_PHASE1 Completed
NCT01156545 2022-04-06
BIBW 2992 Plus Simvastatin vs. BIBW 2992 in Previously Treated Patients With Advanced Non-adenocarcinomatous NSCLC
National Cancer Center, Korea
Phase 2 Completed
NCT01441349 2022-04-06
Irinotecan/Cisplatin With or Without Simvastatin in Chemo-naive Patients With Extensive Disease-small Cell Lung Cancer
National Cancer Center, Korea
Phase 2 Unknown
NCT05133310 2022-01-04
Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia
Hospital General de Mexico
Phase 4 Unknown
NCT04985201 2021-08-09
Combined Simvastatin and Irinotecan in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy
Shanghai Pulmonary Hospital, Shanghai, China
Phase 2 Unknown
NCT04698941 2021-07-29
Combined Simvastatin and Albumin Paclitaxel in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy
Shanghai Pulmonary Hospital, Shanghai, China
Phase 2 Unknown
NCT02061397 2020-08-25
SOS
University of Pennsylvania
Phase 1/2 Completed
NCT04418089 2020-06-05
Simvastatin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response and Tumor-Free Margin in Locally Advanced Breast Cancer
Indonesia University
Phase 2 Completed
NCT02390843 2020-04-03
AflacST1402
Emory University
Phase 1 Completed
NCT02161822 2020-03-25
Capecitabine Plus Simvastatin in Locally Advanced Rectal Cancer Patients
Samsung Medical Center
Phase 2 Unknown
NCT03086291 2019-12-30
A Phase I Study of High Dose Simvastatin in Patients With Gastrointestinal Tract Cancer Who Failed to Standard Chemotherapy
Samsung Medical Center
Phase 1 Unknown
NCT01772719 2019-11-18
Overcoming Chemotherapy Resistance In Refractory Multiple Myeloma With Simvastatin and Zoledronic Acid
University of Louisville
Phase NA Terminated
NCT02285738 2019-05-08
Anti-Platelet and Statin Therapy to Prevent Cancer-Associated Thrombosis
Case Comprehensive Cancer Center
Phase EARLY_PHASE1 Completed
NCT00334542 2019-04-03
Simvastatin in Preventing a New Breast Cancer in Women at High Risk for a New Breast Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Phase 2 Completed
NCT02971410 2018-07-02
Simvastatin in Overcoming Chemotherapy Resistance in Patients With Relapsed or Refractory Multiple Myeloma
Wake Forest University Health Sciences
Phase EARLY_PHASE1 Withdrawn
NCT02026583 2018-01-17
A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-line Chemotherapy in Metastatic Colorectal Cancer Patients
Samsung Medical Center
Phase 2 Completed
NCT01332617 2017-12-29
Phase II Study of Simvastatin for Relapsed/Refractory Myeloma
University of Louisville
Phase 2 Withdrawn
NCT00452244 2017-08-25
Gefitinib With or Without Simvastatin in Non-Small Cell Lung Cancer (NSCLC)
National Cancer Center, Korea
Phase 2 Completed
NCT00572468 2017-07-13
Statin Therapy Versus Placebo Prior to Prostatectomy
VA Office of Research and Development
Phase NA Completed
NCT00656292 2017-05-19
Assessing the Role of "Statin" Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery
Mayo Clinic
Phase 4 Completed
NCT00944463 2017-02-17
Trial of Simvastatin and Gemcitabine in Pancreatic Cancer Patients
Samsung Medical Center
Phase 2 Completed
NCT01099085 2017-02-17
Trial of XP (Capecitabine/CDDP) Simvastatin in Advanced Gastric Cancer Patients
Samsung Medical Center
Phase 3 Completed
NCT02766803 2016-09-08
Effects of Simvastatin and Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) Patients
Poznan University of Medical Sciences
Phase 4 Unknown
NCT02360618 2016-07-11
Metformin and Simvastatin Use in Bladder Cancer
London Health Sciences Centre
Phase 2 Unknown
NCT02104193 2016-02-17
Simvastatin Effect on Radiation Therapy of Brain Metastases
Ain Shams University
Phase 2 Completed
NCT00575965 2015-12-16
Simvastatin in Waldenstrom's Macroglobulinemia
Dana-Farber Cancer Institute
Phase 2 Terminated
NCT01561482 2015-07-22
Study of Metformin With Simvastatin for Men With Prostate Carcinoma
Baylor College of Medicine
Phase 2 Withdrawn
NCT00503763 2015-04-16
PSMMSS
Meir Medical Center
Phase 2 Withdrawn
NCT01500577 2014-06-18
A Prevention Trial in Subjects at High Risk for Breast Cancer
European Institute of Oncology
Phase 2 Completed
NCT00828282 2014-05-26
High-dose HMG-CoA Inhibitor Simvastatin Relapsed CLL
University of Kentucky
Phase 1 Completed
NCT00807950 2014-01-22
Phase II Study of Simvastatin in Primary Breast Cancer; Test of Its Potential Selectivity on Basal Subtype Breast Cancer
National University Hospital, Singapore
Phase 2 Unknown