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9 trials
RecentStart dateEnrollment
XL647 × Clear all

Phase

Phase 2 4Phase 1 3Phase 3 1Phase 1/2 1

Status

Completed 6Terminated 2Withdrawn 1

Sponsor Class

INDUSTRY 9

Study Type

Interventional 9

Sponsor

Cancer Type

Thoracic 5CNS 3Tumor-Agnostic 2Breast 1

Conditions

Carcinoma, Non-Small-Cell Lung 5Neoplasms 3Brain Neoplasms 3Meningeal Carcinomatosis 1Glioblastoma 1Breast Neoplasms 1

Interventions

Cisplatin 3176Cyclophosphamide 3172Carboplatin 2955Radiotherapy 2771Paclitaxel 2705Gemcitabine 2549pembrolizumab 2368Bevacizumab 2192Docetaxel 2190Fluorouracil 1837Capecitabine 1815Oxaliplatin 1723Dexamethasone 1592Nivolumab 1575Doxorubicin 1500Rituximab 1480Magnetic Resonance Spectroscopy 1365Etoposide 1341Irinotecan 1240Leucovorin 1215Drug Therapy 1189Cytarabine 1126Pemetrexed 1067fludarabine 1035Specimen Handling 985Vincristine 964Prednisone 940Cetuximab 938Trastuzumab 936Lenalidomide 932

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements
NCT00086528 2022-05-13

Safety and Pharmacokinetics of XL647 Administered Orally to Subjects With Solid Tumors

Kadmon Corporation, LLC

Phase 1 Completed
41 enrolled
Tumor-Agnostic

Neoplasms

NCT00336765 2022-05-13

Study of XL647 Administered Orally Daily to Patients With Solid Tumors

Kadmon Corporation, LLC

Phase 1 Completed
31 enrolled
Tumor-Agnostic

Neoplasms

NCT00364780 2022-05-13

Study of XL647 in Subjects With Non-Small-Cell Lung Cancer

Kadmon Corporation, LLC

Phase 2 Completed
55 enrolled
Thoracic

Carcinoma, Non-Small-Cell Lung

NCT00522145 2022-05-13

Study of XL647 in Subjects With NSCLC Who Have Progressed After Responding to Treatment With Gefitinib or Erlotinib

Kadmon Corporation, LLC

Phase 2 Completed
41 enrolled
Thoracic

Carcinoma, Non-Small-Cell Lung

NCT01487174 2022-05-13

KD019 Versus Erlotinib in Subjects With Stage IIIB/IV Non Small Cell Lung Cancer With Progression After First- or Second-Line Chemotherapy

Kadmon Corporation, LLC

Phase 3 Terminated
8 enrolled
Thoracic

Carcinoma, Non-Small-Cell Lung

NCT02154529 2022-04-27

Study of the Combination of KD019 and Trastuzumab in Subjects With HER2-Positive Metastatic Breast Cancer

Kadmon Corporation, LLC

Phase 1/2 Terminated
17 enrolled 19 charts
CNS

Brain Neoplasms

NCT02616393 2022-03-16

Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases

Kadmon Corporation, LLC

Phase 2 Completed
36 enrolled 22 charts
CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT02844439 2021-09-22

Study of Tesevatinib Monotherapy in Patients With Recurrent Glioblastoma

Kadmon Corporation, LLC

Phase 2 Completed
40 enrolled 25 charts
CNS

Brain Neoplasms, Glioblastoma

NCT00704392 2015-08-20

Safety Study of XL647 and XL147 Administered in Combination Daily in Adults With Solid Tumors

Exelixis

Phase 1 Withdrawn
BreastThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Neoplasms

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