Clinical Trials

Bronchial Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Respiratory Tract Neoplasms

NCT06613633 2026-04-29

Third-generation EGFR-TKI Treatment in Metastatic EGFR-mutant NSCLC

Completed

4,000 enrolled

Carcinoma, Non-Small-Cell Lung

NCT07548060 2026-04-23

TROP-LUNG

25 enrolled

Carcinoma, Non-Small-Cell Lung

NCT07517640 2026-04-08

Combining Furmonertinib With Local Therapy for Inoperable Early-stage Lung Cancer: A Phase II Trial

45 enrolled

Carcinoma, Non-Small-Cell Lung

NCT06812871 2026-04-02

High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal Metastasis

Phase 2 Completed

46 enrolled

CNS

Meningeal Carcinomatosis

NCT07348965 2026-04-02

Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis

Phase NA Recruiting

42 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT06868732 2026-03-30

Evaluation of JSKN016 Combination Therapy in Subjects With NSCLC

Phase 1 Recruiting

288 enrolled

Advanced Non-small Cell Lung Cancer

NCT07482605 2026-03-20

Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion

63 enrolled

Phase 1 Active not recruiting

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Pleural Effusion, Malignant

NCT05364073 2026-03-13

Study of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating, Including Uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutations

160 enrolled

Carcinoma, Non-Small-Cell Lung

NCT07365410 2026-01-26

Furmonertinib 160mg vs 80mg + Chemotherapy in EGFR-Mutated NSCLC With Brain Metastases: Efficacy and Safety Study

60 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT07314216 2026-01-06

Firmonertinib Combined With Definitive Radiotherapy in Stage III Unresectable EGFR Uncommon Mutant Pulmonary Adenocarcinoma

15 enrolled

Carcinoma, Non-Small-Cell Lung

NCT07304739 2025-12-26

Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT05465343 2025-12-19

Furmonertinib in EGFR-Mutant NSCLC With Brain Metastases (iFORCE)

Phase 2 Completed

24 enrolled

CNS

Brain Neoplasms

NCT06652048 2025-11-21

High-dose Furmonertinib or Combined With Chemotherapy in EGFR-mutant Advanced NSCLC After Disease Progression on Third-generation EGFR-TKI

60 enrolled

Phase 1 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT04858958 2025-11-19

FAVOUR

Phase 2 Active not recruiting

NSCLC

NCT05466149 2025-11-19

Efficacy and Safety of Furmonertinib in Patients With Locally Advanced or Metastatic NSCLC With EGFR Exon 20 Insertion

100 enrolled

NSCLC

NCT07229599 2025-11-17

A Study of MHB036C Combined With Anti-tumor Therapies in Patients With Advanced Lung Cancer

Phase 1/2 Recruiting

300 enrolled

Advanced Lung Cancer

NCT07193160 2025-09-25

Sacituzumab Tirumotecan in Combination With Furmonertinib as Second-line Treatment for EGFR-mutant Advanced or Metastatic NSCLC After Failure of First-line Third-generation EGFR-TKI Therapy

45 enrolled

Carcinoma, Non-Small-Cell Lung

NCT07087223 2025-07-25

Phase Ib/II Study of Vebreltinib With Furmonertinib in NSCLC Patients With c-Met Amplification After EGFR-TKI Failure

Phase 1/2 Recruiting

42 enrolled

Non Small Cell Lung Cancer NSCLC

NCT06962865 2025-07-16

A Phase Ⅱ Study of RC108 in Combination With Furmonertinib for the First-line Treatment of EGFR-Mutated Combined MET-Positive Unresectable Locally Advanced or Recurrent Metastatic NSCLC

80 enrolled

Phase 3 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT05607550 2025-06-22

Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)

398 enrolled

Carcinoma, Non-Small-Cell Lung

NCT04671303 2025-05-11

To Evaluate the Efficacy and Safety of Anlotinib Combined With Furmonertinib Mesylate in Lung Cancer

Phase 2 Completed

36 enrolled

Lung Neoplasms

NCT05994131 2025-04-30

IN10018 Combination Therapy in Advanced EGFR Mutation-positive NSCLC

Phase 1/2 Recruiting

110 enrolled

Phase 3 Active not recruiting

NSCLC

NCT03787992 2025-04-11

Alflutinib Mesylate Versus Gefitinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer （FLAG）

358 enrolled

Locally Advanced or Metastatic EGFR Sensitising Mutation Positive Non-small Cell Lung Cancer

NCT04853342 2025-04-04

FORWARD

Phase 3 Recruiting

318 enrolled

Carcinoma, Non-Small-Cell Lung

NCT02973763 2025-04-03

Safety, Tolerability, Pharmacokinetics and Anti-tumour Activity of Alflutinib in Advanced Non Small Cell Lung Cancer

Phase 1 Terminated

14 enrolled

NSCLC

NCT03127449 2025-04-03

AST2818 in Advanced Non-Small Cell Lung Cancer With EGFR Mutations

Phase NA Terminated

116 enrolled

Advanced NSCLC

NCT03452592 2025-04-03

Efficacy and Safety of Alflutinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer Patients With T790M

Phase 2 Terminated

220 enrolled

Advanced NSCLC Patients With T790M

NCT04958967 2025-03-14

Phase Ib Study of FURMONERTINIB in Patients with NSCLC Having Exon 20 Insertion Mutation

Phase 1 Withdrawn

NSCLC

NCT06643000 2025-03-06

Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis

Phase NA Recruiting

60 enrolled

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT06674343 2024-11-05

Furmonertinib 160mg as First-line Treatment in Locally Advanced or Metastatic NSCLC With EGFR Classical Mutations

Phase 3 Recruiting

144 enrolled

Carcinoma, Non-Small-Cell Lung

NCT04322890 2024-10-22

PIKACHU

6,000 enrolled

Carcinoma, Non-Small-Cell Lung

NCT06537297 2024-09-20

Intrathecal Pemetrexed Combined With High-dose Furmonertinib and Beva for EGFR-m NSCLC With Leptomeningeal Metastases

Carcinoma, Non-Small-Cell Lung

NCT05379803 2024-09-19

High-dose Furmonertinib for First-line Treatment of EGFR Mutated NSCLC With Central Nervous System (CNS) Metastases

40 enrolled

Carcinoma, Non-Small-Cell Lung

NCT06585644 2024-09-05

A Clinical Trial of Furmonertinib Combination Therapy As Neoadjuvant Treatment in Resectable EGFR-Mutated NSCLC

44 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT06394674 2024-07-26

High-dose Furmonertinib in the Treatment in Patients With Advanced, Metastatic NSCLC With Progressed After First- or Second-line Treatment With Osimertinib

84 enrolled

Carcinoma, Non-Small-Cell Lung

NCT06483672 2024-07-03

LungBrain001

27 enrolled

Adenocarcinoma of Lung, Brain Neoplasms

NCT06452433 2024-06-11

Gumarontinib Combined With 3rd EGFR-TKI in Patients With Non-small Cell Lung Cancer.

91 enrolled

Carcinoma, Non-Small-Cell Lung

NCT06352502 2024-04-08

An Observational Study of Furmonertinib for EGFR Mutation-positive NSCLC Patients With Brain Metastasis

Unknown

EGF-R Positive Non-Small Cell Lung Cancer

NCT06339242 2024-04-01

A Study of Furmonertinib Combined With Chemotherapy in the Treatment of NSCLC With Leptomeningeal Metastasis

NSCLC

NCT06319950 2024-03-20

High-dose Furmonertinib Versus Osimertinib in Advanced EGFRm NSCLC Patients With Brain Metastases

255 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT06192849 2024-01-05

To Assess the Efficacy and Safety of Furmonertinib in Patients With Epidermal Growth Factor Receptor 20ins Mutation Positive Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy

20 enrolled

Carcinoma, Non-Small-Cell Lung

NCT04401059 2023-12-27

SELECT-2

Phase 4 Unknown

744 enrolled

Adenocarcinoma, Carcinoma, Carcinoma, Non-Small-Cell Lung

NCT06117644 2023-11-07

The Efficacy of Double-dose Furmonertinib in the Treatment of Patients With Slow Osimertinib-resistant NSCLC

Not yet recruiting

Carcinoma, Non-Small-Cell Lung

NCT05987826 2023-08-14

Study of Furmonertinib as Neoadjuvant Therapy for Resectable Stage Ⅱ-ⅢB EGFR Sensitive Mutant NSCLC

40 enrolled

Carcinoma, Non-Small-Cell Lung

NCT05813522 2023-04-14

Furmonertinib in Patients With Leptomeningeal Metastases Associated With EGFR Mutated NSCLC

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT05445310 2023-02-16

Adjuvant Furmonertinib in Stage IA With High Risk Factors and Stage IB Non-small Cell Lung Cancer

114 enrolled

Carcinoma, Non-Small-Cell Lung

NCT04895930 2023-01-06

FOCUS-A

40 enrolled

Carcinoma, Non-Small-Cell Lung

NCT05548348 2022-09-21

First-line Furmonertinib in Advanced NSCLC Patients With EGFR Uncommon Mutation

Carcinoma, Non-Small-Cell Lung

NCT05334277 2022-08-31

FOCUS-C

280 enrolled