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NCT02306161 2026-05-27

Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma

Phase 3 Active not recruiting

312 enrolled 14 charts

Sarcoma, Ewing

NCT01042379 2026-05-06

I-SPY

Phase 2 Recruiting

Pathologic Complete Response, Breast Neoplasms, Hemangiosarcoma, Neoplasms, Triple Negative Breast Neoplasms

NCT04199026 2026-02-19

Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma

Phase NA Recruiting

Sarcoma

NCT01318642 2024-11-08

Ganitumab in Locally Advanced Unresectable Adenocarcinoma of the Pancreas

Phase 2 Terminated

10 enrolled 10 charts

Gastrointestinal

Adenocarcinoma, Pancreatic Neoplasms

NCT00630552 2024-10-17

QUILT-2.019: A Study of AMG 655 or AMG 479 in Combination With Gemcitabine for Treatment of Metastatic Pancreatic Cancer

Phase 1/2 Completed

138 enrolled 19 charts

Gastrointestinal

Insulin-Like Growth Factor I, Resistance To, Pancreatic Neoplasms

NCT00807612 2024-09-25

QUILT-2.017: Phase 1b/2 Study of AMG 479 in Combination With Paclitaxel and Carboplatin for 1st Line Treatment of Advanced Squamous Non-Small Cell Lung Cancer

Phase 1/2 Terminated

15 enrolled 11 charts

Insulin-Like Growth Factor I, Resistance To

NCT00626106 2024-09-19

QUILT-2.015: A Study of AMG 479 With Exemestane or Fulvestrant in Postmenopausal Women With Hormone Receptor Positive Locally Advanced or Metastatic Breast Cancer

Phase 2 Completed

156 enrolled 16 charts

Breast Neoplasms, Neoplasm Metastasis

NCT00791154 2024-08-23

SCLC

Phase 1/2 Terminated

213 enrolled 16 charts

Lung Neoplasms, Pleural Effusion, Malignant, Small Cell Lung Carcinoma

NCT00819169 2024-08-20

QUILT-3.026: AMG 655 in Combination With AMG 479 in Advanced, Refractory Solid Tumors

Phase 1/2 Terminated

89 enrolled 20 charts

GastrointestinalGynecologicSarcomaThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Sarcoma, Colorectal Neoplasms

NCT00788957 2024-08-07

Panitumumab Combination Study With Rilotumumab or Ganitumab in Wild-type Kirsten Rat Sarcoma Virus Oncogene Homolog (KRAS) Metastatic Colorectal Cancer (mCRC)

Phase 1/2 Completed

177 enrolled 31 charts

Gastrointestinal

Colonic Neoplasms, Gastrointestinal Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04129151 2024-08-01

Palbociclib + Ganitumab In Ewing Sarcoma

Phase 2 Terminated

10 enrolled 15 charts

Recurrence, Sarcoma, Sarcoma, Ewing

NCT00891930 2024-07-17

Study to Evaluate Mechanisms of Acquired Resistance to Panitumumab

Phase 2 Completed

74 enrolled 15 charts

Gastrointestinal

Colorectal Neoplasms

NCT01231347 2024-07-16

GAMMA

Phase 3 Completed

800 enrolled 11 charts

Gastrointestinal

Endocrine Gland Neoplasms, Jaundice, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms

NCT03041701 2022-04-14

Insulin-like Growth Factor 1 Receptor (IGF-1R) Antibody AMG479 (Ganitumab) in Combination With the Src Family Kinase (SFK) Inhibitor Dasatinib in People With Embryonal and Alveolar Rhabdomyosarcoma

Phase 1/2 Terminated

14 enrolled 17 charts

Rhabdomyosarcoma, Rhabdomyosarcoma, Alveolar, Rhabdomyosarcoma, Embryonal

NCT01327612 2021-02-21

Open Label Extension Study of Conatumumab and Ganitumab (AMG 479)

Phase 2 Completed

12 enrolled 21 charts

EndocrineGastrointestinalLymphoidSarcomaThoracic

Carcinoid Tumor, Carcinoma, Non-Small-Cell Lung, Lymphoma, Neoplasm Metastasis, Sarcoma, Colorectal Neoplasms

NCT01562899 2020-12-10

A Study of MEK162 and AMG 479 in Patients With Selected Solid Tumors

Phase 1/2 Terminated

Melanoma

NCT01061788 2019-08-28

RAP

Phase 1 Completed

Carcinoma, Non-Small-Cell Lung

NCT03029481 2019-03-28

Single Patient Expanded Access to Ganitumab for Metastatic Ewing Sarcoma

No longer available

Sarcoma, Ewing

NCT01708161 2018-09-13

A Phase Ib/II Study of the Combination of BYL719 Plus AMG 479 in Adult Patients With Selected Solid Tumors

Phase 1/2 Terminated

47 enrolled 23 charts

BreastGynecologic

Breast Neoplasms, Ovarian Neoplasms

NCT01024387 2018-03-08

AMG 479 in Advanced Carcinoid and Pancreatic Neuroendocrine Tumors

Phase 2 Completed

60 enrolled 7 charts

Carcinoid Tumor, Adenoma, Islet Cell, Neuroendocrine Tumors

NCT01122199 2017-05-10

Study of RAD001 + AMG479 for Patients With Advanced Solid Tumors

Phase 1 Completed

Neoplasm Metastasis

NCT00563680 2016-10-27

QUILT-3.025: A Phase 2 Study of AMG 479 in Relapsed or Refractory Ewing's Family Tumor and Desmoplastic Small Round Cell Tumors

Phase 2 Completed

Askin Tumor, Insulin-Like Growth Factor I, Resistance To, Sarcoma, Sarcoma, Ewing, Neuroectodermal Tumors, Primitive

NCT00813605 2016-10-27

QUILT-2.018: Safety & Efficacy of FOLFIRI With AMG 479 or AMG 655 vs FOLFIRI Alone in KRAS-mutant Metastatic Colorectal Carcinoma

Phase 2 Completed

Gastrointestinal

Adenocarcinoma, Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00974896 2016-10-27

QUILT-2.016: Study of AMG 479 With Biologics or Chemotherapy for Subjects With Advanced Solid Tumors

Phase 1 Completed

Neoplasms

NCT01479179 2016-10-26

Trastuzumab in Combination With AMG 479 in HER-2 Overexpressing MBC Progressing on Trastuzumab

Phase 1/2 Withdrawn

Breast Neoplasms

NCT01473303 2016-06-28

Combination Chemotherapy With or Without Ganitumab in Treating Patients With Previously Untreated Metastatic Pancreatic Cancer

Phase 1/2 Withdrawn

Gastrointestinal

Pancreatic Neoplasms

NCT00718523 2016-01-12

Study of Adding AMG 479 to First Line Chemotherapy in Patients With Optimally Debulked Epithelial Ovarian Cancer

Phase 2 Terminated

170 enrolled 20 charts

Ovarian Neoplasms

NCT00719212 2016-01-11

Study of AMG 479 as Second Line Therapy in Patients With Recurrent Platinum-sensitive Ovarian Cancer

Phase 2 Completed

61 enrolled 22 charts

Ovarian Neoplasms

NCT01298401 2015-11-17

Ganitumab and Gemcitabine Hydrochloride Followed by Radiation Therapy, Ganitumab, Capecitabine, and Maintenance Therapy in Treating Patients With Locally Advanced Cancer of the Pancreas

Phase 1 Completed

Gastrointestinal

Pancreatic Neoplasms

NCT00562380 2013-07-18

AMG-479 in Treating Patients With Advanced Solid Tumors or Non-Hodgkin Lymphoma

Phase 1 Completed

DermatologicGenitourinaryLymphoidOther hematologic neoplasmSarcoma

Burkitt Lymphoma, Immunoblastic Lymphadenopathy, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Prostatic Neoplasms, Sarcoma, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, Large-Cell, Anaplastic, Neuroectodermal Tumors, Primitive, Peripheral, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Desmoplastic Small Round Cell Tumor