Clinical Trials Browser

motesanib diphosphate × Clear all

NCT01349088 2025-05-02

Investigational Drug in Combination With Two Chemotherapy Drugs in Women With Locally Recurrent or Metastatic Breast Cancer

Phase 1/2 Withdrawn

Breast Neoplasms

NCT00427349 2023-07-05

AMG 706 and Octreotide in Treating Patients With Low-Grade Neuroendocrine Tumors

Phase 2 Completed

46 enrolled 7 charts

Vipoma, Glucagonoma, Insulinoma, Adenoma, Islet Cell, Neoplasms, Somatostatinoma, Gastrinoma, Carcinoma, Islet Cell, Neuroendocrine Tumors

NCT00574951 2018-01-11

AMG 706 in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

Phase 2 Terminated

23 enrolled 9 charts

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT00369070 2018-01-04

A Phase 2 Trial of AMG 706 or Bevacizumab in Combination With Chemo for Advanced NSCLC

Phase 2 Terminated

Carcinoma, Non-Small-Cell Lung

NCT00861419 2017-02-08

To Evaluate the Safety, Tolerability and Pharmacokinetics of AMG 386 When Used in Combination With AMG 706, Bevacizumab, Sorafenib, or Sunitinib.

Phase 1 Completed

Other solid neoplasm

Advanced Solid Tumors

NCT00094835 2016-03-24

Study to Evaluate Motesanib With or Without Carboplatin/Paclitaxel or Panitumumab in the Treatment of Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

Phase 1/2 Completed

51 enrolled 23 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02629848 2015-12-14

Study of Motesanib (AMG 706) in Combination With Paclitaxel and Carboplatin for Advanced Non-Squamous Non-Small Cell Lung Cancer

Phase 3 Terminated

Carcinoma, Non-Small-Cell Lung

NCT00356681 2015-10-15

A Study of AMG 706 or Bevacizumab, in Combination With Paclitaxel Chemotherapy, as Treatment for Breast Cancer

Phase 2 Terminated

Breast Neoplasms

NCT00360867 2015-10-15

An Open Label Treatment Extension Study of AMG 706

Phase 2 Terminated

Other solid neoplasm

Solid Tumors

NCT00460317 2015-09-07

MONET1-MOtesanib NSCLC Efficacy and Tolerability Study

Phase 3 Terminated

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT00101907 2014-03-20

Safety of AMG 706 Plus Panitumumab Plus Gemcitabine-Cisplatin in the Treatment of Patients With Advanced Cancer

Phase 1 Terminated

41 enrolled 17 charts

GastrointestinalThoracic

Esophageal Neoplasms, Lung Neoplasms, Pancreatic Neoplasms

NCT00254267 2014-02-27

Evaluate the Efficacy of AMG 706 to Treat Advanced Gastrointestinal Stromal Tumors

Phase 2 Completed

GastrointestinalSarcoma

Gastrointestinal Stromal Tumors

NCT00121628 2013-10-09

A Phase 2, Open-label Study of AMG 706 to Treat Subjects With Locally Advanced or Metastatic Thyroid Cancer

Phase 2 Completed

EndocrineHead & Neck

Thyroid cancer, Hurthle cell, Thyroid Cancer, Papillary, Thyroid Neoplasms, Adenocarcinoma, Follicular, Carcinoma, Medullary

NCT00324597 2013-09-17

AMG 706 and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma

Phase 1 Unknown

DermatologicLymphoidOther hematologic neoplasmThoracic

Adenocarcinoma of Lung, Burkitt Lymphoma, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Hodgkin Disease, Immunoblastic Lymphadenopathy, Lung Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Lymphoproliferative Disorders, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

NCT00322400 2013-07-31

Phase1b to Evaluate Safety of AMG706 in Combination With Paclitaxel or Docetaxel for Breast Cancer

Phase 1 Completed

Breast Neoplasms, Neoplasm Metastasis, Neoplasms

NCT00093873 2013-05-15

Study Evaluating AMG 706 in Subjects With Advanced Solid Tumors

Phase 1 Completed

Neoplasms

NCT00089960 2013-04-29

Study of AMG 706 in Subjects With Advanced Gastrointestinal Stromal Tumors (GISTs)

Phase 2 Completed

Gastrointestinal

Gastrointestinal Neoplasms

NCT00101894 2012-09-17

Safety of AMG 706 Plus Panitumumab Plus Chemotherapy in the Treatment of Subjects With Metastatic Colorectal Cancer

Phase 1 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT01386866 2011-07-15

Single Dose Study of [14C]-Labelled AMG 706 in Patients With Advanced Solid Tumors

Phase 1 Completed

Other solid neoplasm

Advanced Solid Tumors

NCT00448786 2011-01-21

Effect of Different Doses of AMG 706 on the Gallbladder in Advanced Solid Tumors

Phase 1 Completed

Other solid neoplasm

Solid Tumors

NCT01235416 2011-01-21

A Phase 1b, Open-label, Dose-finding Study of AMG 706 in Combination With Gemcitabine and Erlotinib to Treat Subjects With Solid Tumors

Phase 1 Completed

Other solid neoplasm

Histologically or Cytologically Documented Solid Tumors