Clinical Trials Browser

Completed × motesanib diphosphate × Clear all

Vipoma, Glucagonoma, Insulinoma, Adenoma, Islet Cell, Neoplasms, Somatostatinoma, Gastrinoma, Carcinoma, Islet Cell, Neuroendocrine Tumors

NCT00861419 2017-02-08

To Evaluate the Safety, Tolerability and Pharmacokinetics of AMG 386 When Used in Combination With AMG 706, Bevacizumab, Sorafenib, or Sunitinib.

Phase 1 Completed

88 enrolled

Other solid neoplasm

Advanced Solid Tumors

NCT00094835 2016-03-24

Study to Evaluate Motesanib With or Without Carboplatin/Paclitaxel or Panitumumab in the Treatment of Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

Phase 1/2 Completed

51 enrolled 23 charts

Thoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00254267 2014-02-27

Evaluate the Efficacy of AMG 706 to Treat Advanced Gastrointestinal Stromal Tumors

Phase 2 Completed

35 enrolled

GastrointestinalSarcoma

Gastrointestinal Stromal Tumors

NCT00121628 2013-10-09

A Phase 2, Open-label Study of AMG 706 to Treat Subjects With Locally Advanced or Metastatic Thyroid Cancer

Phase 2 Completed

184 enrolled

EndocrineHead & Neck

Thyroid cancer, Hurthle cell, Thyroid Cancer, Papillary, Thyroid Neoplasms, Adenocarcinoma, Follicular, Carcinoma, Medullary

NCT00322400 2013-07-31

Phase1b to Evaluate Safety of AMG706 in Combination With Paclitaxel or Docetaxel for Breast Cancer

Phase 1 Completed

46 enrolled

Breast

Breast Neoplasms, Neoplasm Metastasis, Neoplasms

NCT00093873 2013-05-15

Study Evaluating AMG 706 in Subjects With Advanced Solid Tumors

Phase 1 Completed

71 enrolled

Tumor-Agnostic

Neoplasms

NCT00089960 2013-04-29

Study of AMG 706 in Subjects With Advanced Gastrointestinal Stromal Tumors (GISTs)

Phase 2 Completed

138 enrolled

Gastrointestinal

Gastrointestinal Neoplasms

NCT00101894 2012-09-17

Safety of AMG 706 Plus Panitumumab Plus Chemotherapy in the Treatment of Subjects With Metastatic Colorectal Cancer

Phase 1 Completed

119 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT01386866 2011-07-15

Single Dose Study of [14C]-Labelled AMG 706 in Patients With Advanced Solid Tumors

Phase 1 Completed

4 enrolled

Other solid neoplasm

Advanced Solid Tumors

NCT00448786 2011-01-21

Effect of Different Doses of AMG 706 on the Gallbladder in Advanced Solid Tumors

Phase 1 Completed

49 enrolled

Other solid neoplasm

Solid Tumors

NCT01235416 2011-01-21

A Phase 1b, Open-label, Dose-finding Study of AMG 706 in Combination With Gemcitabine and Erlotinib to Treat Subjects With Solid Tumors

Phase 1 Completed

57 enrolled

Other solid neoplasm

Histologically or Cytologically Documented Solid Tumors

Clinical Trials

AMG 706 and Octreotide in Treating Patients With Low-Grade Neuroendocrine Tumors

To Evaluate the Safety, Tolerability and Pharmacokinetics of AMG 386 When Used in Combination With AMG 706, Bevacizumab, Sorafenib, or Sunitinib.

Study to Evaluate Motesanib With or Without Carboplatin/Paclitaxel or Panitumumab in the Treatment of Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

Evaluate the Efficacy of AMG 706 to Treat Advanced Gastrointestinal Stromal Tumors

A Phase 2, Open-label Study of AMG 706 to Treat Subjects With Locally Advanced or Metastatic Thyroid Cancer

Phase1b to Evaluate Safety of AMG706 in Combination With Paclitaxel or Docetaxel for Breast Cancer

Study Evaluating AMG 706 in Subjects With Advanced Solid Tumors

Study of AMG 706 in Subjects With Advanced Gastrointestinal Stromal Tumors (GISTs)

Safety of AMG 706 Plus Panitumumab Plus Chemotherapy in the Treatment of Subjects With Metastatic Colorectal Cancer

Single Dose Study of [14C]-Labelled AMG 706 in Patients With Advanced Solid Tumors

Effect of Different Doses of AMG 706 on the Gallbladder in Advanced Solid Tumors

A Phase 1b, Open-label, Dose-finding Study of AMG 706 in Combination With Gemcitabine and Erlotinib to Treat Subjects With Solid Tumors