Clinical Trials

405 enrolled 34 charts 3 FDA

Phase 3 Active not recruiting

Metastatic Castration Resistant Prostate Cancer

NCT03522246 2025-06-24

ATHENA

1,097 enrolled 26 charts

Carcinoma, Ovarian Epithelial, Pathologic Complete Response, Fallopian Tube Neoplasms, Neoplasms

NCT03442556 2025-06-12

Docetaxel, Carboplatin, and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair Deficiency

18 enrolled

Phase 2 Active not recruiting

ATM Gene Mutation

NCT02678182 2025-06-10

PLATFORM

494 enrolled

Adenocarcinoma of the Oesophagus

NCT03639935 2025-06-03

Rucaparib in Combination With Nivolumab in Patients With Advanced or Metastatic Biliary Tract Cancer Following Platinum Therapy

32 enrolled 14 charts

Biliary Tract Neoplasms, Neoplasm Metastasis

NCT03845296 2025-05-21

Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

Phase 1/2 Active not recruiting

64 enrolled 17 charts

Thoracic

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04253262 2025-05-04

A Study of Copanlisib Combined With Rucaparib in Patients With Metastatic Castration-resistant Prostate Cancer

13 enrolled

Metastatic Castration-resistant Prostate Cancer

NCT04209595 2025-03-17

PLX038 (PEGylated SN38) and Rucaparib in Solid Tumors and Small Cell Cancers

Phase 1/2 Completed

10 enrolled 13 charts

Thoracic

Small Cell Lung Carcinoma

NCT03552471 2025-02-13

Mirvetuximab Soravtansine and Rucaparib Camsylate in Treating Participants With Recurrent Endometrial, Ovarian, Fallopian Tube or Primary Peritoneal Cancer

25 enrolled

Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT04826198 2024-12-05

REVOCAN

Phase 1/2 Terminated

13 enrolled

Ovarian Neoplasms

NCT04227522 2024-11-15

MAMOC

42 enrolled

Fallopian Tube Neoplasms, Ovarian Neoplasms, Adenocarcinoma, Clear Cell

NCT03958045 2024-10-22

Combination Rucaparib With Nivolumab in Small Cell Lung Carcinoma

33 enrolled 15 charts

Thoracic

Small Cell Lung Carcinoma

NCT03413995 2024-10-16

TRIUMPH

12 enrolled 11 charts

Phase EARLY_PHASE1 Completed

Prostate Cancer Metastatic

NCT03911453 2024-10-03

Window of Opportunity Trial, PARP Inhibitor Rucaparib Affect on PD-L1 Expression in Triple Negative Breast Tumors

20 enrolled

Breast

Breast Neoplasms

NCT01074970 2024-09-19

PARP Inhibition for Triple Negative Breast Cancer (ER-/PR-/HER2-)With BRCA1/2 Mutations

Phase 1/2 Active not recruiting

135 enrolled 14 charts

Breast

Breast Neoplasms

NCT03337087 2024-05-17

Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer

18 enrolled 12 charts

Gastrointestinal Neoplasms, Colorectal Neoplasms

NCT04676334 2024-05-07

CATCH-R

34 enrolled 9 charts

GenitourinaryGynecologic

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Genital Neoplasms, Male, Ovarian Neoplasms, Prostatic Neoplasms

NCT03533946 2024-03-13

ROAR

7 enrolled 10 charts

Prostatic Neoplasms

NCT03476798 2024-02-15

Clovis-001

49 enrolled 13 charts

BreastGenitourinaryGynecologic

Uterine Cervical Neoplasms, Endometrial Neoplasms

NCT02925234 2024-01-24

DRUP

Phase 2 Recruiting

1,550 enrolled

Tumor-Agnostic

Neoplasms

NCT03992131 2024-01-16

A Study to Evaluate Rucaparib in Combination With Other Anticancer Agents in Participants With a Solid Tumor (SEASTAR)

Phase 1/2 Terminated

25 enrolled 11 charts

Carcinoma, Transitional Cell, Ovarian Neoplasms, Triple Negative Breast Neoplasms

NCT03840200 2023-10-30

A Study Evaluating the Safety, Pharmacokinetics and Efficacy of Ipatasertib Administered in Combination With Rucaparib in Participants With Advanced Breast, Ovarian Cancer, and Prostate Cancer.

BreastGenitourinaryGynecologic

51 enrolled 20 charts

Breast Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms

NCT04171700 2023-10-02

LODESTAR

BreastGastrointestinalGenitourinaryGynecologicSarcomaThoracic

83 enrolled 16 charts

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinosarcoma, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Fallopian Tube Neoplasms, Leiomyosarcoma, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT03140670 2023-09-28

Maintenance Rucaparib in BRCA1, BRCA2 or PALB2 Mutated Pancreatic Cancer That Has Not Progressed on Platinum-based Therapy

46 enrolled 16 charts

Pancreatic Neoplasms

NCT04179396 2023-06-29

RAMP

8 enrolled 8 charts

Metastatic Castration Resistant Prostate Cancer

NCT02042378 2023-06-13

A Study of Rucaparib in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation

19 enrolled

Pancreatic Neoplasms

NCT01891344 2023-06-12

ARIEL2

491 enrolled 19 charts

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Neoplasms, Recurrence

NCT03824704 2023-06-12

A Study to Evaluate Rucaparib in Combination With Nivolumab in Patients With Selected Solid Tumors (ARIES)

1 enrolled 7 charts

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Carcinoma, Endometrioid

NCT01482715 2023-06-09

A Study of Oral Rucaparib in Patients With a Solid Tumor (Phase I) or With gBRCA Mutation Ovarian Cancer (Phase II)

Phase 1/2 Completed

136 enrolled 30 charts

Fallopian Tube Neoplasms, Ovarian Neoplasms, Recurrence

NCT01968213 2023-06-09

ARIEL3

564 enrolled 18 charts 2 FDA

Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT02740712 2023-06-09

DDI

17 enrolled

Tumor-Agnostic

Neoplasms

NCT02855944 2023-06-09

ARIEL4: A Study of Rucaparib Versus Chemotherapy BRCA Mutant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients

349 enrolled 29 charts

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Neoplasms, Recurrence

NCT02935634 2023-06-09

FRACTION-GC

190 enrolled 25 charts

Advanced Gastric Cancer

NCT02952534 2023-06-09

TRITON2

277 enrolled 23 charts 3 FDA

Mental Retardation, X-Linked, With Or Without Seizures, Arx-Related

NCT02986100 2023-06-09

AME

6 enrolled

Other solid neoplasm

Solid Tumor

NCT03397394 2023-06-09

ATLAS

97 enrolled 12 charts

Urinary Bladder Neoplasms, Carcinoma, Transitional Cell, Ureteral Neoplasms, Urethral Neoplasms

NCT03499444 2023-06-09

A Study of Rucaparib in Japanese Patients With a Previously-treated Solid Tumor

29 enrolled

Other solid neoplasm

Advanced Solid Tumor

NCT03521037 2023-06-09

Rucaparib Hepatic Impairment Study in Patients With a Solid Tumor