Clinical Trials

Genitourinary

Non-Muscle Invasive Bladder Neoplasms

NCT06834074 2026-05-14

NVL-655-EAP

Carcinoma, Non-Small-Cell Lung

NCT04571229 2026-05-11

Expanded Access Use of L-MTP-PE for the Treatment of Osteosarcoma

Osteosarcoma

NCT05028166 2026-05-08

Individual Patient Compassionate Use of Mirdametinib

Neurofibromatoses, Neurofibroma, Plexiform

NCT05041036 2026-05-08

Individual Patient Compassionate Use of Nirogacestat

Desmoid Tumors

NCT06915766 2026-05-08

Expanded Access to Bezuclastinib for Patients With NonAdvanced Systemic Mastocytosis or Advanced Systemic Mastocytosis

LymphoidMyeloidOther hematologic neoplasm

Leukemia, Mast-Cell, Mastocytosis, Systemic

NCT06948955 2026-05-08

Expanded Access to Bezuclastinib to be Coadministered With Sunitinib for Patients With Gastrointestinal Stromal Tumors

GastrointestinalSarcoma

Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors

NCT07573215 2026-05-07

Expanded Access Program for Daraxonrasib (RMC-6236) in Previously Treated Metastatic Pancreatic Adenocarcinoma

Gastrointestinal

Pancreatic Neoplasms

NCT05572970 2026-05-06

Expanded Access for Cancer Treatment With Balstilimab (AGEN2034) and Zalifrelimab (AGEN1884)

Neoplasms

NCT07535359 2026-05-06

Medical Access Program for Ifinatamab Deruxtecan in 3L+ Pretreated Extensive-stage Small Cell Lung Cancer

Small Cell Lung Carcinoma

NCT06761976 2026-05-05

Expanded Access to Provide Sevabertinib (BAY 2927088) for the Treatment of Locally Advanced or Metastatic NSCLC With HER2 Mutation

Neoplasms

NCT01916148 2026-04-27

18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic Hypoglycemia

Endocrine

Beckwith-Wiedemann Syndrome, Hyperinsulinism, Hypoglycemia, Insulinoma, Congenital Hyperinsulinism

NCT07536815 2026-04-27

An Open-Label, Multicenter, Non-Randomized Expanded Access Protocol (EAP) Designed to Provide Leronlimab to Patients With Locally Advanced or Metastatic Triple-Negative Breast Cancer (mTNBC)

Breast

Triple Negative Breast Neoplasms

NCT05511714 2026-04-24

Expanded Access [11C] Methionine PET Imaging

CNSHead & Neck

Head and Neck Neoplasms, Central Nervous System Neoplasms

NCT05593185 2026-04-24

Expanded Access Program (EAP) for Galinpepimut-S (GPS) in Patients Diagnosed With AML or MDS

MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Hematologic Neoplasms

NCT03601442 2026-04-23

Managed Access Programs for CTL019, Tisagenlecleucel

LymphoidOther hematologic neoplasm

Leukemia, Lymphoma

NCT05398640 2026-04-20

Expanded Access Program of AMTAGVI That is Out of Specification for Commercial Release

Dermatologic

Melanoma

NCT04085653 2026-04-14

Managed Access Programs for BYL719, Alpelisib

Breast

Breast Neoplasms

NCT06443944 2026-04-14

An Expanded Access Program of Cretostimogene Grenadenorepvec for Treatment of NMIBC for Patients Unresponsive to BCG

Genitourinary

Non-Muscle Invasive Bladder Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Transitional Cell, Urologic Neoplasms

NCT01163383 2026-04-13

131-I-MIBG Therapy for Refractory Neuroblastoma, Expanded Access Protocol

Neuroblastoma

NCT05038631 2026-04-13

Managed Access Programs for LEE011, Ribociclib

Breast

Breast Neoplasms

NCT05776134 2026-04-08

Expanded Access Study for the Treatment of Patients With Commercially Out-of-Specification Brexucabtagene Autoleucel

LymphoidOther hematologic neoplasm

Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT07502716 2026-03-31

Compassionate Use of Ubamatamab

NCT07497984 2026-03-27

ITM11 Expanded Access Program

Meningioma

NCT04091295 2026-03-04

BLESSED: Expanded Access for DNG64-CAR-V for Advanced Pancreatic Cancer, Sarcoma and Carcinoma of Breast

BreastGastrointestinalGenitourinaryGynecologicSarcomaThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Chondrosarcoma, Chordoma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Osteosarcoma, Neurofibrosarcoma

NCT07215832 2026-03-02

KEAP

GynecologicLymphoidMyeloidPlasma cellSarcoma

Multiple Myeloma, Sarcoma, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Peripheral, Endometrial Neoplasms, Primary Myelofibrosis

NCT06799221 2026-02-27

Expanded Access Program for OOS Obe-cel

LymphoidOther hematologic neoplasm

Burkitt Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT06836648 2026-02-25

Single Patient Compassionate Use of X-PACT in Salvage Treatment of Prostate Cancer

Genitourinary

Prostatic Neoplasms

NCT03581240 2026-02-20

An Intermediate Expanded Use Trial of DFMO

Typical Teratoid Rhabdoid Tumor, Medulloblastoma, Neuroblastoma, Neuroectodermal Tumors, Primitive

NCT06797362 2026-02-17

Expanded Access Program of Zidesamtinib (NVL-520) for Patients With Advanced ROS1+ NSCLC or Other ROS1+ Solid Tumors

Carcinoma, Non-Small-Cell Lung

NCT05346835 2026-02-13

Expanded Access Program (EAP) for Ciltacabtagene Autoleucel (Cilta-Cel) Out-of-Specification (OOS) in Participants With Multiple Myeloma

Plasma cell

Multiple Myeloma

NCT06617572 2026-02-09

Expanded Access Protocol (EAP) for Nonconforming (NC) Afami-cel

Sarcoma, Synovial, Liposarcoma, Myxoid

NCT05982873 2026-02-06

Expanded Access to Telisotuzumab Adizutecan

Other solid neoplasm

Solid Tumors

NCT03123029 2026-01-30

Expanded Access to Venetoclax

LymphoidOther hematologic neoplasmPlasma cell

Amyloidosis, Leukemia, Plasma Cell, Lymphoma, Non-Hodgkin, Multiple Myeloma, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT07310277 2026-01-29

Expanded Access to ABBV-706

Small Cell Lung Carcinoma

NCT04566393 2026-01-28

Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies

CNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Glioblastoma, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT06963697 2026-01-15

Expanded Access To Neoantigen Synthetic Long Peptide Vaccines in Patients With Local Or Metastatic Solid Tumors

Neoplasms

NCT06910137 2026-01-08

An Early Access Program Guideline to Provide Access to Retifanlimab (INCMGA00012) Together With Carboplatin and Paclitaxel for Squamous Carcinoma of the Anal Canal (SCAC)

Gastrointestinal

Anus Neoplasms, Carcinoma, Squamous Cell

NCT03626285 2026-01-02

Bone Marrow Transplantation Using CD34-Selected Stem Cells From Related or Unrelated Donors in Treating Participants With Cancer or Other Disorders

Neoplasms

NCT05619367 2025-12-23

A Compassionate Use (CU) Program of Odronextamab

Lymphoid

Lymphoma, Follicular, Recurrence, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse

NCT04771078 2025-12-12

Expanded Access Protocol (EAP) for Participants Receiving Idecabtagene Vicleucel That is Nonconforming for Commercial Release

Plasma cell

Multiple Myeloma

NCT04400591 2025-12-11

Nonconforming Lisocabtagene Maraleucel Expanded Access Protocol

Lymphoid

Lymphoma, Large B-Cell, Diffuse

NCT04360005 2025-12-05

Managed Access Programs for ABL001, Asciminib

MyeloidOther hematologic neoplasm

Leukemia, Myelogenous, Chronic, BCR-ABL Positive

NCT07262970 2025-12-04

Intermediate-Size Cohort EAP for Ersodetug in Patients With Inadequately Controlled Hypoglycemia Related to a Tumor

EndocrineNETSarcoma

Fibrosarcoma, Hyperinsulinism, Hypoglycemia, Insulinoma, Adenoma, Islet Cell, Liposarcoma, Neoplasms, Neuroectodermal Tumors, Primitive, Neuroendocrine Tumors

NCT05776160 2025-12-01

Expanded Access Study for the Treatment of Patients With Commercially Out-of-Specification Axicabtagene Ciloleucel

Lymphoid

Lymphoma, Follicular

NCT01881334 2025-11-20

Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood Transplants

Classical hematologyLymphoidMyeloidOther hematologic neoplasm

Adrenoleukodystrophy, Anemia, Aplastic, Anemia, Sickle Cell, Immunologic Deficiency Syndromes, Lymphoma, Metabolic Diseases, Myelodysplastic Syndromes, Thalassemia, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT04745637 2025-11-18

Managed Access Programs for INC424, Ruxolitinib

Myeloid

Polycythemia Vera, Primary Myelofibrosis

NCT07218224 2025-10-20

Expanded Access:18F-Fluorocholine for the Detection of Parathyroid Adenomas